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Figure 2 — Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt
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Created: 2026-04-21T18:29:40
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Figure 2Figure 2
Neutrophil-microglial contacts in lumbar parenchyma, AQP4-IgG infusion day 3. ( A ) Confocal image identifies putatively interacting microglia (Cx3cr1GFP + , green) and neutrophil (Ly6G + , red) adjacent to a neuronal soma (NeuN + , blue); subsequent images are Imaris 3D rendering. ( B ) Cord region of interest containing contacting neutrophil-microglia; laser-branded frame by 2-photon imaging; magnified. ( C ) Serial block-face scanning electron microscopy (SBF-SEM) shows ultrastructurally the same neutrophil, microglia, and 2 neurons boxed in A . Yellow arrows (magnified, C1 ) indicate contacting microglial-neutrophil somata edges (green and red lines in C2 ). ( D ) 3D serial reconstruction of contacting microglial-neutrophil somata in C ( Supplemental Video 1 , Z -stack). ( E ) Representative confocal image (left, 2,048 × 2,048 pixel; ×63 objective lens) and 3D rendering image (right) show microglial process and soma interacting with Ly6G + neutrophils in lumbar parenchyma of
▸Metadata
| pmid | paper-41665955 |
| caption | Neutrophil-microglial contacts in lumbar parenchyma, AQP4-IgG infusion day 3. ( A ) Confocal image identifies putatively interacting microglia (Cx3cr1GFP + , green) and neutrophil (Ly6G + , red) adjac |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13038209/bin/jci-136-199706-g002.jpg |
| paper_title | Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG. |
| figure_label | Figure 2 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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