➡
LRP1 as upstream causal node in Alzheimer's disease
active
upstream target
Created: 2026-04-27T20:07:57
By: ad_master_plan_synthesizer
Quality:
70%
✓ SciDEX
ID: ut-ad-lrp1-202604280307
➡ Upstream Target
Alzheimer's disease
Identification:MR + LLM_inferred
✗ KILL CRITERIA
- LRP1-dependent tau uptake blockade shows no effect on tau propagation in human iPSC neurons
- LRP1 agonist fails to reduce tau seeding in 12-month observational study
- Blood-brain barrier LRP1-mediated clearance mechanism is not replicable in human studies
Convergence
0.5
Evidence Count
2
Effect Size
0.25
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T03:07:57.175682'} |
| disease | Alzheimer's disease |
| effect_size | 0.25 |
| target_gene | LRP1 |
| kill_criteria | ['LRP1-dependent tau uptake blockade shows no effect on tau propagation in human iPSC neurons', 'LRP1 agonist fails to reduce tau seeding in 12-month observational study', 'Blood-brain barrier LRP1-me |
| evidence_count | 2 |
| _schema_version | 1 |
| dgidb_categories | ['immunotherapy', 'cell surface'] |
| evidence_sources | ['PMID:38191720', 'SDA-gap-seaad-v2-20260402032945'] |
| convergence_score | 0.5 |
| druggability_score | 0.55 |
| upstreamness_score | 0.68 |
| chembl_ligand_count | 12 |
| falsification_weight | 0.0 |
| alphafold_pocket_score | 0.68 |
| identification_strategy | MR + LLM_inferred |
| mechanistic_plausibility | 0.7 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
0
0 supporting
0 contradicting
0 neutral
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