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Krause End Bulbs

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wiki page Created: 2026-04-02T07:19:45 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-cell-types-krause-end-bulbs
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Krause End Bulbs

Krause End Bulbs


<table class="infobox infobox-cell">
<tr>
<th class="infobox-header" colspan="2">Krause End Bulbs</th>
</tr>
<tr>
<td class="label">Gene/Protein</td>
<td>Function</td>
</tr>
<tr>
<td class="label">TRPM8</td>
<td>Cold detection</td>
</tr>
<tr>
<td class="label">TRPA1</td>
<td>Chemical/thermal nociception</td>
</tr>
<tr>
<td class="label">P2RX3</td>
<td>ATP-gated ion channel</td>
</tr>
<tr>
<td class="label">NGF</td>
<td>Neuronal survival</td>
</tr>
<tr>
<td class="label">BDNF</td>
<td>Neurotrophin</td>
</tr>
</table>

Introduction

Krause End Bulbs is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

Krause end bulbs are encapsulated thermoreceptors found in the skin, mucous membranes, and connective tissue. They are sensitive to cold temperatures (typically 10-20°C) and are named after Wilhelm Krause who first described them in 1860. [@johnson2000]

Krause End Bulbs

Structure

  • Capsule: Connective tissue envelope surrounding the nerve ending
  • Core: Central nerve terminal with mitochondria and vesicles
  • Axon: Small myelinated Aδ fiber
  • Location: Skin, lips, tongue, conjunctiva, genitalia, joint capsules

Function


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📊 Evidence Profile Foundational
Evidence Balance
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75%
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Outgoing
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