Vagal Afferent Microbial Signal Modulation

## **Molecular Mechanism and Rationale** The vagus nerve represents a critical bidirectional communication highway between the gut microbiome and the central nervous system, with vagal afferent neurons serving as primary transducers of microbial metabolites and inflammatory signals. This hypothesis proposes that targeted modulation of vagal afferent signaling through manipulation of GLP1R (glucagon-like peptide-1 receptor) and BDNF (brain-derived neurotrophic factor) pathways can provide diseas...