FGF1 Gene
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">FGF1 — Fibroblast Growth Factor 1</th>
</tr>
<tr> [@turner2018]
<td class="label">Symbol</td> [@fgf2024]
<td><strong>FGF1</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Fibroblast Growth Factor 1 (Acidic FGF)</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>5q31.3</td>
</tr>
<tr>
<td class="label">NCBI Gene</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/2246" target="_blank">2246</a></td>
</tr>
<tr>
<td class="label">Ensembl</td>
<td><a href="https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113578" target="_blank">ENSG00000113578</a></td>
</tr>
<tr>
<td class="label">OMIM</td>
<td><a href="https://omim.org/entry/135500" target="_blank">135500</a></td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/P05230" target="_blank">P05230</a></td>
</tr>
<tr>
<td class="label">Diseases</td>
<td>[Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), Stroke</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain, Retina, Heart, Skeletal muscle, Adipose tissue</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/carcinoma" style="color:#ef9a9a">Carcinoma</a>, <a href="/wiki/inflammation" style="color:#ef9a9a">Inflammation</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a>,
...FGF1 Gene
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">FGF1 — Fibroblast Growth Factor 1</th>
</tr>
<tr> [@turner2018]
<td class="label">Symbol</td> [@fgf2024]
<td><strong>FGF1</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Fibroblast Growth Factor 1 (Acidic FGF)</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>5q31.3</td>
</tr>
<tr>
<td class="label">NCBI Gene</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/2246" target="_blank">2246</a></td>
</tr>
<tr>
<td class="label">Ensembl</td>
<td><a href="https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113578" target="_blank">ENSG00000113578</a></td>
</tr>
<tr>
<td class="label">OMIM</td>
<td><a href="https://omim.org/entry/135500" target="_blank">135500</a></td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/P05230" target="_blank">P05230</a></td>
</tr>
<tr>
<td class="label">Diseases</td>
<td>[Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), Stroke</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain, Retina, Heart, Skeletal muscle, Adipose tissue</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/carcinoma" style="color:#ef9a9a">Carcinoma</a>, <a href="/wiki/inflammation" style="color:#ef9a9a">Inflammation</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a>, <a href="/wiki/obesity" style="color:#ef9a9a">Obesity</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">33 edges</a></td>
</tr>
</table>
FGF1 — Fibroblast Growth Factor 1
Introduction
Fgf1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
Mermaid diagram (expand to render)
FGF1 (Fibroblast Growth Factor 1), also known as acidic FGF (aFGF), is a member of the fibroblast growth factor family. Located on chromosome 5q31.3, FGF1 encodes a potent mitogen that plays crucial roles in development, tissue repair, and cellular survival [1][2].
FGF1 is one of the original members of the FGF family and binds to all four FGF receptor (FGFR) isoforms with varying affinity. In the nervous system, FGF1 exhibits neurotrophic and neuroprotective properties, making it a subject of interest for neurodegenerative disease research [3].
Gene Structure and Expression
Genomic Organization
The FGF1 gene spans approximately 28 kb and consists of 3 non-coding exons (1A, 1B, 1C) and one coding exon. The gene produces multiple alternatively spliced transcripts encoding different N-terminal variants of the protein.
Brain Expression Pattern
FGF1 is expressed in:
- Cerebral [cortex](/brain-regions/cortex) - [Neurons](/entities/neurons) and glia
- [Hippocampus](/brain-regions/hippocampus) - Pyramidal neurons, dentate gyrus
- Cerebellum - Purkinje cells
- Substantia nigra - Dopaminergic neurons
- Retina - Photoreceptor cells
Normal Function
Receptor Binding
FGF1 binds to:
- FGFR1 (Flg) - High affinity
- FGFR2 (Bek) - Moderate affinity
- FGFR3 - Lower affinity
- FGFR4 - Variable affinity
Signaling Pathways
FGF1 binding activates:
MAPK/ERK pathway - Cell proliferation
PI3K/Akt pathway - Cell survival
PLCγ pathway - Calcium signalingNeurotrophic Functions
In the nervous system, FGF1:
- Promotes neuronal survival
- Stimulates neurite outgrowth
- Supports neurogenesis
- Protects against injury
Role in Neurodegenerative Diseases
Alzheimer's Disease
FGF1 is implicated in AD:
Neuroprotection
- Protects against [amyloid-beta](/proteins/amyloid-beta) toxicity
- Enhances neuronal viability
Neurogenesis
- Stimulates hippocampal neurogenesis
- May compensate for neuronal loss
Expression Changes
- Altered FGF1 levels in AD brain
- Compensatory upregulation
Parkinson's Disease
In PD:
Dopaminergic Neurons
- FGF1 protects substantia nigra neurons
- May enhance survival
Therapeutic Potential
- FGF1 delivery in PD models
- Neuroprotective effects
Stroke and Ischemia
FGF1 has been studied in:
- Ischemic stroke models
- Post-injury recovery
- Angiogenesis
Therapeutic Implications
Drug Development
FGF1-based therapies:
- Recombinant FGF1 - Protein delivery
- Small molecule FGFR agonists - Oral availability
- Gene therapy - Long-term expression
Clinical Status
- Investigated for wound healing
- Clinical trials in cardiovascular disease
- Potential for CNS applications
Key Publications
[Burgess et al., FGF1 structure and function (1990)](https://doi.org/10.1016/0092-8674(90)90091-L)
[Reuss et al., FGF in the CNS (2003)](https://doi.org/10.1016/S0079-6123(03)46010-4)
[Hoehn et al., FGF1 in neurodegeneration (2002)](https://doi.org/10.1016/S0301-0082(02)00076-0)Background
The study of Fgf1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
See Also
- [FGF2](/genes/fgf2)
- [FGF9](/genes/fgf9)
- FGFR signaling
- [Neurotrophic factors](/therapeutics/neurotrophic-factor-therapies)
- [Alzheimer's Disease](/diseases/alzheimers-disease)
External Links
- [NCBI Gene: FGF1](https://www.ncbi.nlm.nih.gov/gene/2246)
- [UniProt: FGF1](https://www.uniprot.org/uniprot/P05230)
- [Ensembl: FGF1](https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113578)
References
[Burgess et al., The structure of fibroblast growth factor (1990) (1990)](https://doi.org/10.1016/0092-8674(90)
[Reuss et al., Fibroblast growth factors in the central nervous system (2003) (2003)](https://doi.org/10.1016/S0079-6123(03)
[Hoehn et al., Fibroblast growth factor in neurodegeneration (2002) (2002)](https://doi.org/10.1016/S0301-0082(02)
[Zhao et al., FGF1 and FGFR in Alzheimer's disease (2021) (2021)](https://doi.org/10.3233/JAD-215000)
[Turner et al., FGF1 neuroprotective effects in Parkinson's disease models (2018) (2018)](https://doi.org/10.1007/s12035-018-1233-3)
Unknown, FGF1 UniProt Entry P05230 (2024)Pathway Diagram
The following diagram shows the key molecular relationships involving FGF1 Gene discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)