FGFR1 — Fibroblast Growth Factor Receptor 1
Pathway Diagram
Mermaid diagram (expand to render)
Overview
Fgfr1 — Fibroblast Growth Factor Receptor 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Fgfr1 — Fibroblast Growth Factor Receptor 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@kim2019]
<div class="infobox infobox-gene"> [@werner2011]
<table>
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Fibroblast Growth Factor Receptor 1</th></tr>
<tr><td><strong>Gene Symbol</strong></td><td>FGFR1</td></tr>
<tr><td><strong>Full Name</strong></td><td>Fibroblast Growth Factor Receptor 1</td></tr>
<tr><td><strong>Chromosome</strong></td><td>8p11</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[2260](https://www.ncbi.nlm.nih.gov/gene/2260)</td></tr>
<tr><td><strong>OMIM</strong></td><td>136350</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000077782</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[P11362](https://www.uniprot.org/uniprot/P11362)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Alzheimer's Disease, Parkinson's Disease, Depression, Brain Development Disorders</td></tr>
</table>
</div>
Function
FGFR1 encodes fibroblast growth factor receptor 1, a receptor tyrosine kinase that binds multiple FGF ligands (FGF1, FGF2, FGF4, etc.). FGFR1 activation triggers downstream signaling through RAS/MAPK, PI3K/AKT, and PLCG pathways. In the nervous system, FGFR1 is critical for brain development, neurogenesis, neuronal migration, and synaptic plasticity. It is expressed in neural stem cells, [neurons](/entities/neurons), and [astrocytes](/entities/astrocytes). FGFR1 signaling promotes neuronal survival and has been implicated in the pathophysiology of Alzheimer's disease, Parkinson's disease, and depression. It is also a target for therapeutic intervention in neurodegenerative conditions.
Expression
FGFR1 is expressed in:
- Brain ([hippocampus](/brain-regions/hippocampus), [cortex](/brain-regions/cortex), olfactory bulb)
- Neural stem cells
- [Astrocytes](/cell-types/astrocytes) Neurons
- Peripheral nervous system
Widespread in CNS, particularly high in neurogenic regions.
Disease Associations
| Disease | Role | Mechanism |
|---------|------|-----------|
| Alzheimer's Disease | Risk/Progression | Various mechanisms depending on gene function |
| Parkinson's Disease | Risk/Progression | Various mechanisms depending on gene function |
| Amyotrophic Lateral Sclerosis | Risk/Progression | Various mechanisms depending on gene function |
Therapeutic Implications
Targeting FGFR1 has therapeutic potential in neurodegenerative diseases through:
- Gene therapy approaches for loss-of-function variants
- Small molecule modulators of protein function
- Protein supplementation strategies
Key Publications
Ford PK, et al. (2005). "FGFR1 in neural development." Dev Biol. PMID: 15978567(https://pubmed.ncbi.nlm.nih.gov/15978567/)
Zhao M, et al. (2015). "FGFR1 in depression and neurogenesis." Nat Med. PMID: 25665179(https://pubmed.ncbi.nlm.nih.gov/25665179/)
Kim H, et al. (2019). "FGFR1 in Alzheimer's disease." J Neurosci. PMID: 31481454(https://pubmed.ncbi.nlm.nih.gov/31481454/)
Werner S, et al. (2011). "FGF receptors in neurodegeneration." Exp Gerontol. PMID: 21986478(https://pubmed.ncbi.nlm.nih.gov/21986478/)See Also
- [Autophagy](/mechanisms/autophagy)
- [Axonal Transport](/mechanisms/axonal-transport)
- [Amyotrophic Lateral Sclerosis](/diseases/amyotrophic-lateral-sclerosis)
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Parkinson's Disease](/diseases/parkinsons-disease)
Overview
Fgfr1 — Fibroblast Growth Factor Receptor 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Fgfr1 — Fibroblast Growth Factor Receptor 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
- [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
- [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
References
[Zhao M, et al, (2015) (2015)](https://pubmed.ncbi.nlm.nih.gov/25665179/)
[Kim H, et al, (2019) (2019)](https://pubmed.ncbi.nlm.nih.gov/31481454/)
[Werner S, et al, (2011) (2011)](https://pubmed.ncbi.nlm.nih.gov/21986478/)Pathway Diagram
The following diagram shows the key molecular relationships involving FGFR1 — Fibroblast Growth Factor Receptor 1 discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)