gene

FGF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections
0Hypotheses
0Analyses
42Outgoing
12Incoming

Summary

FGF1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, protects against, expressed in. Associated with Cancer, Carcinoma, Inflammation. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolFGF1
Chromosome5q31.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionBrain, Retina, Heart, Skeletal muscle, Adipose tissue
Molecular Weight17 kDa
Amino Acids155 aa
PathwaysMAPK, PI3K
UniProt IDP05230
NCBI Gene ID2246
Ensembl IDENSG00000113578
OMIM135500
GeneCardsFGF1
Human Protein AtlasFGF1
Symbol [@fgf2024] FGF1 Full NameFibroblast Growth Factor 1 (Acidic FGF)
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Stroke
InteractionsERK1, FGF2, PIEZO1, IL1A, FGFR2, DNA
KG Connections54 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: FGF1 — AlphaFold P05230 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

FGF1 Gene

gene · 672 words

FGF10 — Fibroblast Growth Factor 10

gene · 3796 words

FGF Signaling Pathway in Neurodegeneration

mechanism · 3211 words

FGF Signaling in Parkinson's Disease

mechanism · 2485 words

Fibroblast Growth Factor Signaling in Neurodegeneration

mechanism · 1987 words

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

mechanism · 1710 words

Pathway Diagram

graph TD
    FGF1["<b>FGF1</b>"]
    FGFR1["FGFR1"]
    FGF1 -->|"activates"| FGFR1
    Cancer{"Cancer"}
    FGF1 -->|"expressed in"| Cancer
    Inflammation{"Inflammation"}
    FGF1 -->|"activates"| Inflammation
    Obesity{"Obesity"}
    FGF1 -->|"activates"| Obesity
    Ms{"Ms"}
    FGF1 -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    FGF1 -->|"interacts with"| Carcinoma
    ERK1["ERK1"]
    FGF1 -->|"interacts with"| ERK1
    FGF2["FGF2"]
    FGF1 -->|"interacts with"| FGF2
    Angiogenesis(["Angiogenesis"])
    FGF1 -->|"interacts with"| Angiogenesis
    DNA["DNA"]
    FGF1 -->|"interacts with"| DNA
    FGF1 -->|"regulates"| FGFR1
    PIEZO1["PIEZO1"]
    FGF1 -->|"activates"| PIEZO1
    PIEZO1 -->|"causes"| FGF1
    ERK1 -->|"interacts with"| FGF1
    PECAM1["PECAM1"]
    PECAM1 -->|"protects against"| FGF1
    FOS["FOS"]
    FOS -->|"protects against"| FGF1
    DNA -->|"interacts with"| FGF1
    AND["AND"]
    AND -->|"interacts with"| FGF1
    FGF2 -->|"interacts with"| FGF1
    style FGF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

TargetRelationTypeStr
FGFR1activatesprotein0.90
Cancerexpressed_indisease0.65
Inflammationactivatesdisease0.65
Obesityactivatesdisease0.65
Msinteracts_withdisease0.65

Incoming (12)

SourceRelationTypeStr
PIEZO1causesprotein0.90
ERK1interacts_withgene0.60
PECAM1protects_againstgene0.60
FOSprotects_againstgene0.60
FGF2interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found