Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FGF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FGF1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, protects against, expressed in. Associated with Cancer, Carcinoma, Inflammation. Connected to 31 entities in the SciDEX knowledge graph.
| Gene Symbol | FGF1 |
| Chromosome | 5q31.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Brain, Retina, Heart, Skeletal muscle, Adipose tissue |
| Molecular Weight | 17 kDa |
| Amino Acids | 155 aa |
| Pathways | MAPK, PI3K |
| UniProt ID | P05230 |
| NCBI Gene ID | 2246 |
| Ensembl ID | ENSG00000113578 |
| OMIM | 135500 |
| GeneCards | FGF1 |
| Human Protein Atlas | FGF1 |
| Symbol [@fgf2024] FGF1 Full Name | Fibroblast Growth Factor 1 (Acidic FGF) |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Stroke |
| Interactions | ERK1, FGF2, PIEZO1, IL1A, FGFR2, DNA |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FGF1["<b>FGF1</b>"]
FGFR1["FGFR1"]
FGF1 -->|"activates"| FGFR1
Cancer{"Cancer"}
FGF1 -->|"expressed in"| Cancer
Inflammation{"Inflammation"}
FGF1 -->|"activates"| Inflammation
Obesity{"Obesity"}
FGF1 -->|"activates"| Obesity
Ms{"Ms"}
FGF1 -->|"interacts with"| Ms
Carcinoma{"Carcinoma"}
FGF1 -->|"interacts with"| Carcinoma
ERK1["ERK1"]
FGF1 -->|"interacts with"| ERK1
FGF2["FGF2"]
FGF1 -->|"interacts with"| FGF2
Angiogenesis(["Angiogenesis"])
FGF1 -->|"interacts with"| Angiogenesis
DNA["DNA"]
FGF1 -->|"interacts with"| DNA
FGF1 -->|"regulates"| FGFR1
PIEZO1["PIEZO1"]
FGF1 -->|"activates"| PIEZO1
PIEZO1 -->|"causes"| FGF1
ERK1 -->|"interacts with"| FGF1
PECAM1["PECAM1"]
PECAM1 -->|"protects against"| FGF1
FOS["FOS"]
FOS -->|"protects against"| FGF1
DNA -->|"interacts with"| FGF1
AND["AND"]
AND -->|"interacts with"| FGF1
FGF2 -->|"interacts with"| FGF1
style FGF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| FGFR1 | activates | protein | 0.90 |
| Cancer | expressed_in | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Obesity | activates | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Carcinoma | interacts_with | disease | 0.65 |
| ERK1 | interacts_with | gene | 0.60 |
| FGF2 | interacts_with | gene | 0.60 |
| FGFR1 | regulates | gene | 0.60 |
| PIEZO1 | activates | gene | 0.60 |
| FGF5 | protects_against | gene | 0.60 |
| IL1A | interacts_with | gene | 0.60 |
| XBP1 | protects_against | gene | 0.60 |
| DNAJB9 | protects_against | gene | 0.60 |
| ERN1 | protects_against | gene | 0.60 |
| PDIA6 | protects_against | gene | 0.60 |
| FGF2 | inhibits | entity | 0.60 |
| FGF2 | expressed_in | gene | 0.60 |
| FGF9 | expressed_in | gene | 0.60 |
| FGFR1 | expressed_in | gene | 0.60 |
| FGFR2 | activates | gene | 0.60 |
| Angiogenesis | interacts_with | pathway | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| FN1 | protects_against | gene | 0.60 |
| Unfolded Protein Response | interacts_with | pathway | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| ERK1/2 | interacts_with | gene | 0.60 |
| FGF | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Endothelial | interacts_with | cell_type | 0.60 |
| Stem Cell | interacts_with | cell_type | 0.60 |
| Fibroblast | interacts_with | cell_type | 0.60 |
| Raf | expressed_in | protein | 0.60 |
| App | expressed_in | protein | 0.60 |
| Erk | interacts_with | protein | 0.60 |
| PTN | activates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Endothelial Cell | expressed_in | cell_type | 0.55 |
| Fibroblast | expressed_in | cell_type | 0.55 |
| Stem Cell | expressed_in | cell_type | 0.55 |
| cancer | expressed_in | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIEZO1 | causes | protein | 0.90 |
| ERK1 | interacts_with | gene | 0.60 |
| PECAM1 | protects_against | gene | 0.60 |
| FOS | protects_against | gene | 0.60 |
| FGF2 | interacts_with | gene | 0.60 |
| CSF1 | activates | gene | 0.60 |
| CSF1R | activates | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| CANCER | expressed_in | entity | 0.60 |
| FGF | interacts_with | gene | 0.60 |
| ERK1/2 | interacts_with | gene | 0.60 |
| FGF | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||