gene 528 words KG: FGFR1 2026-03-21
kind:genesection:genesstate:published
Contents

FGFR1 — Fibroblast Growth Factor Receptor 1

🧬 Gene Info
Gene SymbolFGFR1
Full NameFibroblast Growth Factor Receptor 1
Chromosome8p11
FunctionFGFR1 encodes fibroblast growth factor receptor 1, a receptor tyrosine kinase that binds multiple FGF ligands (FGF1, FGF2, FGF4, etc.).
Primary Expressionneural stem cells, neurons, and astrocytes
PathwaysMAPK, PI3K
UniProt ID[P11362](https://www.uniprot.org/uniprot/P11362)
Ensembl IDENSG00000077782
OMIM136350
GeneCardsFGFR1
Human Protein AtlasFGFR1
Associated DiseasesALS, Cancer, Epilepsy, Glioblastoma, Ms
InteractionsFGF2, FGF21, SOD2, NOX4, SOD1, CX3CR1
KG Connections234 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50

Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

CREB-independent Neuronal Survival Pathways
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
DYRK1A Gene - Dual Specificity Tyrosine-Phosphorylation
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FGFR1 interacts_with FGF2
FGFR1 activates adipogenesis
FGFR1 regulates PIEZO1
FGFR1 therapeutic_target SOX2
FGFR1 therapeutic_target CDK4
FGFR1 therapeutic_target RB1
FGFR1 therapeutic_target CDKN2A
FGFR1 therapeutic_target EZH2
FGFR1 therapeutic_target NSD3
FGFR1 activates FGF21