gene

FGFR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGFR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

234Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for FGFR1 — Fibroblast Growth Factor Receptor 1

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🧬 Gene Info

Gene Symbol	FGFR1
Full Name	Fibroblast Growth Factor Receptor 1
Chromosome	8p11
Function	FGFR1 encodes fibroblast growth factor receptor 1, a receptor tyrosine kinase that binds multiple FGF ligands (FGF1, FGF2, FGF4, etc.).
Primary Expression	neural stem cells, neurons, and astrocytes
Pathways	MAPK, PI3K
UniProt ID	[P11362](https://www.uniprot.org/uniprot/P11362)
Ensembl ID	ENSG00000077782
OMIM	136350
GeneCards	FGFR1
Human Protein Atlas	FGFR1
Associated Diseases	ALS, Cancer, Epilepsy, Glioblastoma, Ms
Interactions	FGF2, FGF21, SOD2, NOX4, SOD1, CX3CR1
KG Connections	234 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGFR1["<b>FGFR1</b>"]
    adipogenesis["adipogenesis"]
    FGFR1 -->|"activates"| adipogenesis
    KLB["KLB"]
    FGFR1 -->|"interacts with"| KLB
    Hypertension{"Hypertension"}
    FGFR1 -->|"inhibits"| Hypertension
    Ms{"Ms"}
    FGFR1 -->|"inhibits"| Ms
    Als{"Als"}
    FGFR1 -->|"inhibits"| Als
    Inflammation{"Inflammation"}
    FGFR1 -->|"activates"| Inflammation
    Obesity{"Obesity"}
    FGFR1 -->|"activates"| Obesity
    Carcinoma{"Carcinoma"}
    FGFR1 -->|"therapeutic target"| Carcinoma
    Cancer{"Cancer"}
    FGFR1 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    FGFR1 -->|"therapeutic target"| Tumor
    Diabetes{"Diabetes"}
    FGFR1 -->|"activates"| Diabetes
    Neuroinflammation{"Neuroinflammation"}
    FGFR1 -->|"activates"| Neuroinflammation
    FGF1["FGF1"]
    FGF1 -->|"activates"| FGFR1
    FGF21["FGF21"]
    FGF21 -->|"interacts with"| FGFR1
    HSPG2["HSPG2"]
    HSPG2 -->|"activates"| FGFR1
    FGF1 -->|"regulates"| FGFR1
    FGF21 -->|"protects against"| FGFR1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| FGFR1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| FGFR1
    SIRT1["SIRT1"]
    SIRT1 -->|"protects against"| FGFR1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| FGFR1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| FGFR1
    CDK1["CDK1"]
    CDK1 -->|"activates"| FGFR1
    OTUD4["OTUD4"]
    OTUD4 -->|"activates"| FGFR1
    style FGFR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (156)

Target	Relation	Type	Str
adipogenesis	activates	phenotype	0.80
limbal stem cells	expressed_in	cell_type	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
KLB	interacts_with	protein	0.70
Hypertension	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Obesity	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Diabetes	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	associated_with	disease	0.65
Glioblastoma	activates	disease	0.65
Prostate Cancer	inhibits	disease	0.65
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Tumor	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	causes	disease	0.65
Cancer	associated_with	disease	0.65
FGF2	interacts_with	gene	0.60
PIEZO1	regulates	gene	0.60
SOX2	therapeutic_target	gene	0.60
CDK4	therapeutic_target	gene	0.60
RB1	therapeutic_target	gene	0.60
CDKN2A	therapeutic_target	gene	0.60
EZH2	therapeutic_target	gene	0.60
NSD3	therapeutic_target	gene	0.60
FGF21	activates	gene	0.60
SOD2	activates	gene	0.60
NOX4	activates	gene	0.60
SOD1	activates	gene	0.60
SIRT1	protects_against	gene	0.60
CX3CR1	inhibits	gene	0.60
AKT	inhibits	gene	0.60

Incoming (78)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
VEGF-B	binds_to	protein	0.95
FGF1	activates	protein	0.90
FGF21	interacts_with	protein	0.70
ACETYLCHOLINE	causes	phenotype	0.65
CYTOKINES	inhibits	phenotype	0.65
CYTOKINES	regulates	phenotype	0.65
HSPG2	activates	gene	0.60
FGF1	regulates	gene	0.60
FGF21	protects_against	gene	0.60
SIRT1	protects_against	gene	0.60
CDK1	activates	gene	0.60
OTUD4	activates	gene	0.60
GBM	activates	gene	0.60
PTEN	activates	gene	0.60
TNF	activates	gene	0.60
FGF9	inhibits	gene	0.60
TNFRSF1A	regulates	gene	0.60
STAT3	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CSF1	regulates	gene	0.60
IL6ST	regulates	gene	0.60
BRAF	biomarker_for	gene	0.60
NRG1	biomarker_for	gene	0.60
TP53	biomarker_for	gene	0.60
FGF21	activates	entity	0.60
SOD1	activates	gene	0.60
SOD2	activates	gene	0.60
NOX4	activates	gene	0.60
NRAS	associated_with	gene	0.60
NF1	associated_with	gene	0.60
DYRK1A	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
EGF	activates	gene	0.60
GBM	associated_with	gene	0.60
AKT3	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
TUBULIN	activates	gene	0.60
BRAF	associated_with	gene	0.60
RHEB	associated_with	gene	0.60
NURR1	activates	gene	0.60
BRAF	interacts_with	gene	0.60
FGF1	expressed_in	gene	0.60
FGF2	expressed_in	gene	0.60
FGF9	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FGFR1

Understanding Entity Pages

Summary

Wiki Pages (21)

FGFR1 — Fibroblast Growth Factor Receptor 1

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

ncam2

Growth Factor Therapeutics: Investment Landscape Analysis

Neurogenesis

Alzheimer's Disease Synaptic Repair and Neuroprotection Companies

FGF Signaling Pathway in Neurodegeneration

Adult Neurogenesis in Neurodegenerative Disease

AAV Gene Therapy Vectors for Neurodegeneration

FGF7 — Fibroblast Growth Factor 7

FGF Signaling in Parkinson's Disease

FGF6 Gene

FGF8 Gene

Section 143: Advanced Neurogenesis and Neural Stem Cell Activation in CBS/PSP

FGF21 — Fibroblast Growth Factor 21

Fibroblast Growth Factor Signaling in Neurodegeneration

Innate Immune Response in Neurodegeneration

FGF16 Gene

Alpha-Klotho in Neurodegeneration