HOMER2 Gene

HOMER2 — Homer Scaffold Protein 2

Overview

Homer2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Homer2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@xiao1998]

<div class="infobox infobox-gene"> [@tu1999]
<table> [@rong2003]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Homer Scaffold Protein 2</th></tr> [@hayashi2005]
<tr><td><strong>Gene Symbol</strong></td><td>HOMER2</td></tr> [@hu2009]
<tr><td><strong>Full Name</strong></td><td>Homer Scaffold Protein 2</td></tr> [@sun2013]
<tr><td><strong>Chromosome</strong></td><td>15q24.3</td></tr> [@zhang2019]
<tr><td><strong>NCBI Gene ID</strong></td><td>[9455](https://www.ncbi.nlm.nih.gov/gene/9455)</td></tr>
<tr><td><strong>OMIM</strong></td><td>604869</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000124827</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q9NSC5](https://www.uniprot.org/uniprot/Q9NSC5)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Alzheimer's Disease, Schizophrenia, Autism Spectrum Disorders, Epilepsy</td></tr>
</table>
</div>

Function

HOMER2 — Homer Scaffold Protein 2

Overview

Homer2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Homer2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@xiao1998]

<div class="infobox infobox-gene"> [@tu1999]
<table> [@rong2003]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Homer Scaffold Protein 2</th></tr> [@hayashi2005]
<tr><td><strong>Gene Symbol</strong></td><td>HOMER2</td></tr> [@hu2009]
<tr><td><strong>Full Name</strong></td><td>Homer Scaffold Protein 2</td></tr> [@sun2013]
<tr><td><strong>Chromosome</strong></td><td>15q24.3</td></tr> [@zhang2019]
<tr><td><strong>NCBI Gene ID</strong></td><td>[9455](https://www.ncbi.nlm.nih.gov/gene/9455)</td></tr>
<tr><td><strong>OMIM</strong></td><td>604869</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000124827</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q9NSC5](https://www.uniprot.org/uniprot/Q9NSC5)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Alzheimer's Disease, Schizophrenia, Autism Spectrum Disorders, Epilepsy</td></tr>
</table>
</div>

Function

HOMER2 encodes Homer 2, a scaffolding protein that organizes postsynaptic density structures and regulates synaptic signaling. Homer proteins bind to group I metabotropic glutamate receptors (mGluR1/5), Shank proteins, and other synaptic components. Homer 2 is particularly important for mGluR5 signaling, calcium homeostasis, and synaptic plasticity. Reduced Homer 2 expression has been reported in Alzheimer's disease brains, contributing to disrupted glutamatergic signaling and synaptic dysfunction.

Expression

High expression in brain, particularly in the cerebral [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), and cerebellum. Expressed in [neurons](/entities/neurons) at postsynaptic densities.

Disease Associations

| Disease | Mechanism |
|---------|-----------|
| Alzheimer's Disease | |
| Schizophrenia | |
| Autism Spectrum Disorders | |
| Epilepsy | |

Interactions

| Partner | Interaction Type | Pathway |
|---------|-----------------|---------|

Research

Key Findings

• [Reference 1](https://pubmed.ncbi.nlm.nih.gov/) -
• [Reference 2](https://pubmed.ncbi.nlm.nih.gov/) -

Clinical Trials

No clinical trials directly targeting this gene are currently registered for neurodegenerative diseases.

Overview

Homer2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Homer2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

See Also

• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Amyloid Hypothesis](/mechanisms/amyloid-hypothesis)
• [Tau Pathology](/mechanisms/tau-pathology)
• [/mechanisms/synaptic-dysfunction-ad](/mechanisms/synaptic-dysfunction)
• [/entities/nmda-receptor](/entities/nmda-receptor)

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

External Resources

• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)
• [UniProt](https://www.uniprot.org/uniprot/)
• [Ensembl](https://www.ensembl.org/)
• [GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=)

References