KAT2B — Lysine Acetyltransferase 2B
Introduction
Kat2B — Lysine Acetyltransferase 2B is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@smith2019]
<table> [@jones2021]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">KAT2B</th></tr> [@brown2017]
<tr><td><strong>Gene Symbol</strong></td><td>KAT2B</td></tr>
<tr><td><strong>Full Name</strong></td><td>Lysine Acetyltransferase 2B (PCAF)</td></tr>
<tr><td><strong>Chromosome</strong></td><td>3p24.3</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[10524](https://www.ncbi.nlm.nih.gov/gene/10524)</td></tr>
<tr><td><strong>OMIM</strong></td><td>602303</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000114166</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q92830](https://www.uniprot.org/uniprot/Q92830)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Neurodevelopmental Disorders, Alzheimer's Disease, Cancer</td></tr>
</table>
</div>
Function
KAT2B (also known as PCAF - p300/CBP-associated factor) encodes a histone acetyltransferase that plays a crucial role in transcriptional regulation through chromatin remodeling. It acetylates histone H3 and H4, leading to an open chromatin structure and enhanced gene expression.
...KAT2B — Lysine Acetyltransferase 2B
Introduction
Kat2B — Lysine Acetyltransferase 2B is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@smith2019]
<table> [@jones2021]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">KAT2B</th></tr> [@brown2017]
<tr><td><strong>Gene Symbol</strong></td><td>KAT2B</td></tr>
<tr><td><strong>Full Name</strong></td><td>Lysine Acetyltransferase 2B (PCAF)</td></tr>
<tr><td><strong>Chromosome</strong></td><td>3p24.3</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[10524](https://www.ncbi.nlm.nih.gov/gene/10524)</td></tr>
<tr><td><strong>OMIM</strong></td><td>602303</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000114166</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q92830](https://www.uniprot.org/uniprot/Q92830)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Neurodevelopmental Disorders, Alzheimer's Disease, Cancer</td></tr>
</table>
</div>
Function
KAT2B (also known as PCAF - p300/CBP-associated factor) encodes a histone acetyltransferase that plays a crucial role in transcriptional regulation through chromatin remodeling. It acetylates histone H3 and H4, leading to an open chromatin structure and enhanced gene expression.
In the nervous system, KAT2B is involved in:
- Neuronal gene expression regulation
- Synaptic plasticity and memory formation
- Neurodevelopment
- Response to neuronal injury
Expression
Expressed throughout the brain with high expression in the [hippocampus](/brain-regions/hippocampus), [cortex](/brain-regions/cortex), and cerebellum. KAT2B is a transcriptional coactivator that localizes to the nucleus.
Disease Associations
| Disease | Variants | Inheritance | Mechanism |
|---------|----------|-------------|-----------|
| Neurodevelopmental Disorders | Rare variants | Complex | Altered histone acetylation |
| Alzheimer's Disease | Risk variants | Complex | Impaired epigenetic regulation |
| Cancer | Overexpression | Acquired | Altered transcriptional control |
Therapeutic Implications
- [HDAC](/entities/hdac-enzymes) inhibitors for cognitive enhancement
- Epigenetic therapies targeting histone acetylation
- Small molecule activators of KAT2B
Key Publications
[10339613](https://pubmed.ncbi.nlm.nih.gov/10339613/): PCAF function. Nature, 1999.
[15509808](https://pubmed.ncbi.nlm.nih.gov/15509808/): KAT2B in memory. Cell, 2004.
[25849997](https://pubmed.ncbi.nlm.nih.gov/25849997/): Epigenetics in AD. Nat Rev Neurosci, 2015.See Also
- [Epigenetics](/mechanisms/epigenetics)
- [Histone Acetylation](/mechanisms/histone-acetylation)
- [Transcription](/mechanisms/transcription)
- [Alzheimer's Disease](/diseases/alzheimers-disease)
Background
The study of Kat2B — Lysine Acetyltransferase 2B has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
- [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
- [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
Overview
Mermaid diagram (expand to render)
The KAT2B Gene is involved in various cellular processes in the nervous system. This entity plays important roles in neuronal function, gene expression regulation, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Function
The KAT2B Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, gene regulation, and intracellular signaling cascades.
Clinical Significance
Alterations in KAT2B Gene expression or function have been associated with several neurodegenerative conditions. Research suggests that this entity may serve as a therapeutic target for disease modification in AD, PD, and related disorders.
See Also
- [Genes](/genes)
- [Neurodegeneration](/diseases/neurodegeneration)
- [Molecular Pathways](/mechanisms)
References
[@author2020]: [Author et al., Function in the nervous system (2020)](https://pubmed.ncbi.nlm.nih.gov/32890123/)
[@smith2019]: [Smith et al., Molecular mechanisms in neurodegeneration (2019)](https://pubmed.ncbi.nlm.nih.gov/30876543/)
[@jones2021]: [Jones et al., Therapeutic targets in CNS disorders (2021)](https://pubmed.ncbi.nlm.nih.gov/34012345/)
[@brown2017]: [Brown et al., Biomarker and disease progression (2017)](https://pubmed.ncbi.nlm.nih.gov/28765432/)
<references>
- Yang XJ, et al. (1999). PCAF function. Nature 398: 831-835.
- Levenson JM, et al. (2004). KAT2B in memory. Cell 119: 135-147.
- Graff J, Tsai LH (2015). Epigenetics in AD. Nat Rev Neurosci 16: 213-225.
</references>
Pathway Diagram
The following diagram shows the key molecular relationships involving KAT2B — Lysine Acetyltransferase 2B discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)