HDAC3-Selective Inhibition for Clock Reset

**Molecular Mechanism and Rationale** Histone deacetylase 3 (HDAC3) represents a critical epigenetic regulator that orchestrates circadian rhythms and metabolic homeostasis through its role in chromatin remodeling. HDAC3 functions as the catalytic subunit of the nuclear receptor co-repressor (NCoR/SMRT) complex, which removes acetyl groups from specific lysine residues on histones H3 and H4, leading to chromatin condensation and transcriptional repression. The molecular mechanism underlying HDA...