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NPC2 — NPC Intracellular Cholesterol Transporter 2

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-npc2

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Metadata

slug	genes-npc2
entity_type	gene
kg_node_id	NPC2

Linked Artifacts (35)

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

related🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration70%

related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%

related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%

see_also📖Microglia in Neurodegeneration60%

see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%

see_also📖LIPA Gene60%

see_also📖hypotheses-apoe-contributes-alzheimers-disease-regulat60%

see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%

see_also📖SMPD1 Gene - Acid Sphingomyelinase60%

see_also📖Packard Center for ALS Research60%

see_also📖Diseases Overview60%

see_also📖Genes60%

see_also📖npc160%

see_also📖Apoptosis in Neurodegeneration60%

see_also📖APP Gene Dosage Reduction Therapy for Down Syndrome60%

mentions🧪Selective Acid Sphingomyelinase Modulation Therapy50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE Isoform Conversion Therapy50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪Lysosomal Positioning Dynamics Modulation50%

mentions🧪Membrane Cholesterol Gradient Modulators50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

mentions🧪APOE Isoform Expression Across Glial Subtypes40%

mentions🔬Investigate how lipid raft composition (cholesterol metaboli40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Membrane Cholesterol Gradient Modulators40%

related🧪Selective Acid Sphingomyelinase Modulation Therapy40%