Lysosomal Positioning Dynamics Modulation

**Molecular Mechanism and Rationale** The lysosomal positioning dynamics hypothesis centers on the critical role of LAMP1 (Lysosomal-Associated Membrane Protein 1) in orchestrating the subcellular distribution of lysosomes through its interaction with the dynein motor complex. LAMP1, a heavily glycosylated type I transmembrane protein, serves as more than just a structural component of lysosomal membranes—it functions as a key regulatory hub for lysosomal motility and positioning within neurons...