Cdk11 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Cdk11 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
CDK11 encodes cyclin-dependent kinase 11, a serine/threonine kinase expressed as two isoforms (CDK11A and CDK11B) that are 99% identical at the protein level. CDK11 is unique among CDKs as it is expressed from two separate but highly similar genes. The protein has multiple isoforms generated through alternative translation initiation, including a full-length kinase (p110) and a mitosis-specific isoform (p58).
Structure
CDK11 contains the characteristic CDK structure:
N-terminal cyclin-binding domain — interacts with cyclins L and D
Kinase domain — serine/threonine protein kinase active site
C-terminal region — regulatory functions and protein interactions
Multiple isoforms — p110, p58, p48 from alternative translation
The study of Cdk11 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Unknown, CDC2-like kinases: emerging roles in neuronal function (2020) (2020)](https://doi.org/10.1016/j.tics.2020.01.008)
[Unknown, CDK11 in cell cycle and cancer (2019) (2019)](https://doi.org/10.1016/j.tcb.2019.02.007)
[Unknown, CDK11 and RNA processing in neurons (2021) (2021)](https://doi.org/10.1016/j.neuro.2021.01.005)