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disease 1,073 words KG: C9orf72
Contents

Amyotrophic Lateral Sclerosis (ALS)

Disease Info
Associated GenesAMYOTROPHIC LATERAL SCLEROSIS
KG Connections88 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Knowledge Graph

Agent Input

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🌐 Cross-references

OMIMMeSHWikipedia

Related Hypotheses (139)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83SASP-Mediated Complement Cascade Amplification
Score: 0.82Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.80Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78Transcriptional Autophagy-Lysosome Coupling
Score: 0.78Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77CYP46A1 Overexpression Gene Therapy
Score: 0.77Circadian Clock-Autophagy Synchronization
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
pg 1/7Next →

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archivedMicroglial subtypes in neurodegeneration — friend vs foe
neuroscience · archived

Related Experiments (22)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

C9orf72 regulates MMP9
C9orf72 causes Frontotemporal dementia
C9orf72 causes lysosomal dysfunction
C9orf72 regulates TDP-43
CEREBELLUM associated_with C9orf72
C9orf72 interacts_with WDR41
C9orf72 involved_in Autoimmune Response
C9orf72 expressed_in presynaptic terminals
C9orf72 regulates dendritic arborization
C9orf72 expressed_in cerebellum

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