IFNAR2 Protein — Interferon Alpha Receptor 2

IFNAR2 Protein — Interferon Alpha Receptor 2

Overview

Ifnar2 Protein — Interferon Alpha Receptor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Ifnar2 Protein — Interferon Alpha Receptor 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-protein">
<table>
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Interferon Alpha Receptor 2 Protein</th></tr>
<tr><td><strong>Protein Name</strong></td><td>Interferon Alpha Receptor 2</td></tr>
<tr><td><strong>Gene</strong></td><td>[IFNAR2](/genes/ifnar2)</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[P48551](https://www.uniprot.org/uniprot/P48551)</td></tr>
<tr><td><strong>PDB Structure</strong></td><td>1RH2, 3B70</td></tr>
<tr><td><strong>Molecular Weight</strong></td><td>52 kDa (membrane form), 20 kDa (soluble form)</td></tr>
<tr><td><strong>Subcellular Localization</strong></td><td>Plasma membrane (membrane form), secreted (soluble form)</td></tr>
<tr><td><strong>Protein Family</strong></td><td>Class I cytokine receptor family, IFNAR family</td></tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">5 edges</a></td>
</tr>
</table>
</div>

Structure

IFNAR2 Protein — Interferon Alpha Receptor 2

Overview

Ifnar2 Protein — Interferon Alpha Receptor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Ifnar2 Protein — Interferon Alpha Receptor 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-protein">
<table>
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Interferon Alpha Receptor 2 Protein</th></tr>
<tr><td><strong>Protein Name</strong></td><td>Interferon Alpha Receptor 2</td></tr>
<tr><td><strong>Gene</strong></td><td>[IFNAR2](/genes/ifnar2)</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[P48551](https://www.uniprot.org/uniprot/P48551)</td></tr>
<tr><td><strong>PDB Structure</strong></td><td>1RH2, 3B70</td></tr>
<tr><td><strong>Molecular Weight</strong></td><td>52 kDa (membrane form), 20 kDa (soluble form)</td></tr>
<tr><td><strong>Subcellular Localization</strong></td><td>Plasma membrane (membrane form), secreted (soluble form)</td></tr>
<tr><td><strong>Protein Family</strong></td><td>Class I cytokine receptor family, IFNAR family</td></tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">5 edges</a></td>
</tr>
</table>
</div>

Structure

IFNAR2 exists in two isoforms: a membrane-bound receptor and a soluble receptor. The membrane form contains extracellular cytokine-binding domains, a transmembrane helix, and a cytoplasmic domain that recruits JAK1. The soluble form is generated by alternative splicing and proteolytic cleavage, acting as a natural antagonist of type I interferon signaling. IFNAR2 is the primary binding subunit for type I interferons.

Normal Function in the Nervous System

In the CNS, IFNAR2 mediates type I interferon responses:

• Regulation of microglial antiviral responses
• Modulation of astrocyte inflammatory signaling
• Neuronal interferon responses during viral infections
• Synaptic plasticity modulation through interferon-stimulated genes

Role in Disease

| Disease | Role | Mechanism |
|---------|------|-----------|
| Alzheimer's Disease | Risk factor | Chronic neuroinflammation through type I IFN signaling |
| Parkinson's Disease | Risk factor | Altered interferon response in dopaminergic [neurons](/entities/neurons) |
| Multiple Sclerosis | Therapeutic target | IFN-β therapy acts through IFNAR1/IFNAR2 |
| Systemic Lupus Erythematosus | Biomarker | Elevated soluble IFNAR2 as disease marker |

Therapeutic Targeting

• Soluble IFNAR2: Recombinant protein as therapeutic interceptor
• JAK inhibitors: Downstream blockade
• Interferon-blocking therapies: For chronic neuroinflammation

Key Publications

See Also

• [IFNAR2 Gene](/genes/ifnar2)
• [IFNAR1 Protein](/proteins/ifnar1-protein)
• [JAK-STAT Signaling](/mechanisms/jak-stat-signaling-neurodegeneration)
• [Alzheimer's Disease](/diseases/alzheimers-disease)

Overview

Ifnar2 Protein — Interferon Alpha Receptor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Ifnar2 Protein — Interferon Alpha Receptor 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

References

<references>

• de Weerd NA, et al. (2011). Type I IFN receptor. Nat Rev Immunol 11: 503-517.
• Goldmann T, et al. (2015). IFNAR in AD. Nat Neurosci 18: 1746-1755.
• Zhong Z, et al. (2017). Neuroinflammation. Nat Rev Neurosci 18: 415-428.
• Krementsov DN, et al. (2023). Soluble IFNAR2. J Clin Invest 133: e168921.