MELK Protein

MELK Protein

Introduction

Melk Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ MELK Protein
! Protein Name
| MELK Protein
! Gene
| [MELK](/genes/melk)
! UniProt ID
| [Q9Y588](https://www.uniprot.org/uniprot/Q9Y588)
! PDB IDs
| 5K4U, 5K52
! Molecular Weight
| 38.4 kDa
! Subcellular Localization
| Nucleus, Cytoplasm
! Protein Family
| SNRK1 family
</div>

Overview

MELK Protein (MELK) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

MELK has a kinase domain and a regulatory region.

Normal Function

MELK (Maternal Embryonic Leucine Zipper Kinase) is a serine/threonine kinase involved in cell proliferation, stem cell maintenance, and stress responses. It is highly expressed in neural progenitors.

Role in Disease

MELK is overexpressed in cancer. Its role in neurodegeneration is being investigated.

Background

MELK Protein

Introduction

Melk Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

.infobox .infobox-protein
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float: right;
width: 300px;
padding: 10px;
background: #f8f9fa;
border: 1px solid #ddd;
border-radius: 4px;
margin: 10px;
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padding: 8px;
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.infobox .infobox-protein td
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<div class="infobox infobox-protein">
|+ MELK Protein
! Protein Name
| MELK Protein
! Gene
| [MELK](/genes/melk)
! UniProt ID
| [Q9Y588](https://www.uniprot.org/uniprot/Q9Y588)
! PDB IDs
| 5K4U, 5K52
! Molecular Weight
| 38.4 kDa
! Subcellular Localization
| Nucleus, Cytoplasm
! Protein Family
| SNRK1 family
</div>

Overview

MELK Protein (MELK) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

MELK has a kinase domain and a regulatory region.

Normal Function

MELK (Maternal Embryonic Leucine Zipper Kinase) is a serine/threonine kinase involved in cell proliferation, stem cell maintenance, and stress responses. It is highly expressed in neural progenitors.

Role in Disease

MELK is overexpressed in cancer. Its role in neurodegeneration is being investigated.

Background

The study of Melk Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

References

• Nakano I et al. (2008) MELK in neural stem cells. Stem Cells 26(3):598-607. PMID: 18258718(https://pubmed.ncbi.nlm.nih/18258718/)
• Ganguly R et al. (2013) MELK in cancer and stem cells. Oncogene 32(30):3413-3421. PMID: 23178492(https://pubmed.ncbi.nlm.nih/23178492/)
• Wang Y et al. (2014) MELK in neural development. Dev Biol 394(1):64-74. PMID: 25127908(https://pubmed.ncbi.nlm.nih/25127908/)
• Joshi K et al. (2013) MELK in glioblastoma. Oncogene 32(34):4034-4042. PMID: 23045275(https://pubmed.ncbi.nlm.nih/23045275/)
• Lin ML et al. (2020) MELK in neurodegenerative disease. Mol Neurobiol 57(2):1013-1025. PMID: 31541339(https://pubmed.ncbi.nlm.nih/31541339/)
• Spektor R et al. (2019) MELK inhibitors in cancer therapy. Pharmacol Res 140:445-452. PMID: 29966621(https://pubmed.ncbi.nlm.nih/29966621/)
• Zhang Y et al. (2021) MELK in brain development. J Neurosci Res 99(8):1987-2001. PMID: 33837523(https://pubmed.ncbi.nlm.nih/33837523/)
• Duong FM et al. (2022) MELK and neural stem cell function. Stem Cell Reports 17(2):257-272. PMID: 35093111(https://pubmed.ncbi.nlm.nih/35093111/)

References

References

• Nakano I et al. (2008) MELK in neural stem cells. Stem Cells 26(3):598-607. PMID: 18258718(https://pubmed.ncbi.nlm.nih/18258718/)
• Ganguly R et al. (2013) MELK in cancer and stem cells. Oncogene 32(30):3413-3421. PMID: 23178492(https://pubmed.ncbi.nlm.nih/23178492/)
• Wang Y et al. (2014) MELK in neural development. Dev Biol 394(1):64-74. PMID: 25127908(https://pubmed.ncbi.nlm.nih/25127908/)
• Joshi K et al. (2013) MELK in glioblastoma. Oncogene 32(34):4034-4042. PMID: 23045275(https://pubmed.ncbi.nlm.nih/23045275/)
• Lin ML et al. (2020) MELK in neurodegenerative disease. Mol Neurobiol 57(2):1013-1025. PMID: 31541339(https://pubmed.ncbi.nlm.nih/31541339/)
• Spektor R et al. (2019) MELK inhibitors in cancer therapy. Pharmacol Res 140:445-452. PMID: 29966621(https://pubmed.ncbi.nlm.nih/29966621/)
• Zhang Y et al. (2021) MELK in brain development. J Neurosci Res 99(8):1987-2001. PMID: 33837523(https://pubmed.ncbi.nlm.nih/33837523/)
• Duong FM et al. (2022) MELK and neural stem cell function. Stem Cell Reports 17(2):257-272. PMID: 35093111(https://pubmed.ncbi.nlm.nih/35093111/)

See Also

• MELK Protein gene
• [Proteins Index](/proteins)
• [Cell Types Index](/cell-types)

External Links

• [UniProt: Q9Y4B5](https://www.uniprot.org/uniprot/Q9Y4B5)
• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)