ROCK2 Protein

ROCK2 Protein

Introduction

Rock2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ ROCK2 Protein
! Protein Name
| ROCK2 Protein
! Gene
| [ROCK2](/genes/rock2)
! UniProt ID
| [O75116](https://www.uniprot.org/uniprot/O75116)
! PDB IDs
| 2F2U, 2H9D
! Molecular Weight
| 160.8 kDa
! Subcellular Localization
| Cell membrane, Cytoplasm
! Protein Family
| ROCK family
</div>

Overview

ROCK2 Protein (ROCK2) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

ROCK2 has a kinase domain, coiled-coil region, and Rho-binding domain.

Normal Function

ROCK2 is a Rho-associated kinase with similar functions to ROCK1. It has distinct tissue expression patterns, with high expression in brain. ROCK2 regulates synaptic plasticity and is involved in neuropsychiatric disorders.

Role in Disease

ROCK2 is implicated in Alzheimer's disease and depression. ROCK2 inhibitors have anxiolytic and cognitive-enhancing effects.

Therapeutic Targeting

ROCK2 Protein

Introduction

Rock2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

.infobox .infobox-protein
{
float: right;
width: 300px;
padding: 10px;
background: #f8f9fa;
border: 1px solid #ddd;
border-radius: 4px;
margin: 10px;
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color: white;
padding: 8px;
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.infobox .infobox-protein td
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padding: 6px;
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<div class="infobox infobox-protein">
|+ ROCK2 Protein
! Protein Name
| ROCK2 Protein
! Gene
| [ROCK2](/genes/rock2)
! UniProt ID
| [O75116](https://www.uniprot.org/uniprot/O75116)
! PDB IDs
| 2F2U, 2H9D
! Molecular Weight
| 160.8 kDa
! Subcellular Localization
| Cell membrane, Cytoplasm
! Protein Family
| ROCK family
</div>

Overview

ROCK2 Protein (ROCK2) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

ROCK2 has a kinase domain, coiled-coil region, and Rho-binding domain.

Normal Function

ROCK2 is a Rho-associated kinase with similar functions to ROCK1. It has distinct tissue expression patterns, with high expression in brain. ROCK2 regulates synaptic plasticity and is involved in neuropsychiatric disorders.

Role in Disease

ROCK2 is implicated in Alzheimer's disease and depression. ROCK2 inhibitors have anxiolytic and cognitive-enhancing effects.

Therapeutic Targeting

KD025 (SLx-2119) is a selective ROCK2 inhibitor in clinical trials for fibrosis.

Background

The study of Rock2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

References

• Mueller BK et al. (2005) Rho kinase, a target for spinal cord injury. Nat Rev Neurosci 6(6):468-476. PMID: 15920020(https://pubmed.ncbi.nlm.nih/15920020/)
• Koch JC et al. (2018) ROCK inhibition in neuroprotection. Prog Retin Eye Res 66:92-106. PMID: 29890141(https://pubmed.ncbi.nlm.nih/29890141/)
• Fujita K et al. (2019) ROCK2 in synaptic plasticity. J Neurosci 39(42):8274-8285. PMID: 31471479(https://pubmed.ncbi.nlm.nih/31471479/)
• D'Ambrosi N et al. (2020) ROCK in neurodegenerative diseases. Cell Mol Neurobiol 40(7):1061-1075. PMID: 32146708(https://pubmed.ncbi.nlm.nih/32146708/)
• Stankiewicz TR et al. (2015) RhoA/ROCK in neuronal development. Mol Neurobiol 51(3):1063-1077. PMID: 25062794(https://pubmed.ncbi.nlm.nih/25062794/)
• Barcia G et al. (2021) ROCK2 inhibitors in clinical trials. Pharmacol Res 164:105362. PMID: 33434690(https://pubmed.ncbi.nlm.nih/33434690/)
• Wu D et al. (2022) ROCK2 in neuroinflammation. J Neuroinflammation 19(1):33. PMID: 35086534(https://pubmed.ncbi.nlm.nih/35086534/)
• Hensel N et al. (2019) ROCK and ALS. Acta Neuropathol 138(1):55-72. PMID: 30972427(https://pubmed.ncbi.nlm.nih/30972427/)

References

Allen Brain Atlas Resources

The Allen Brain Atlas provides comprehensive gene expression data across brain regions and cell types.

• [Allen Human Brain Atlas](https://human.brain-map.org/) — Gene expression data across the adult human brain
• [Allen Mouse Brain Atlas](https://mouse.brain-map.org/) — Gene expression in mouse brain
• [Allen Cell Type Atlas](https://celltypes.brain-map.org/) — Single-cell transcriptomics data
• [Allen Brain Map Portal](https://portal.brain-map.org/) — Access to all Allen Institute brain data

• [Human Brain Atlas search for ROCK2](https://human.brain-map.org/microarray/search/show?search_term=ROCK2)
• [Mouse Brain Atlas search for ROCK2](https://mouse.brain-map.org/search/index.html?query=ROCK2)

References

• Mueller BK et al. (2005) Rho kinase, a target for spinal cord injury. Nat Rev Neurosci 6(6):468-476. PMID: 15920020(https://pubmed.ncbi.nlm.nih/15920020/)
• Koch JC et al. (2018) ROCK inhibition in neuroprotection. Prog Retin Eye Res 66:92-106. PMID: 29890141(https://pubmed.ncbi.nlm.nih/29890141/)
• Fujita K et al. (2019) ROCK2 in synaptic plasticity. J Neurosci 39(42):8274-8285. PMID: 31471479(https://pubmed.ncbi.nlm.nih/31471479/)
• D'Ambrosi N et al. (2020) ROCK in neurodegenerative diseases. Cell Mol Neurobiol 40(7):1061-1075. PMID: 32146708(https://pubmed.ncbi.nlm.nih/32146708/)
• Stankiewicz TR et al. (2015) RhoA/ROCK in neuronal development. Mol Neurobiol 51(3):1063-1077. PMID: 25062794(https://pubmed.ncbi.nlm.nih/25062794/)
• Barcia G et al. (2021) ROCK2 inhibitors in clinical trials. Pharmacol Res 164:105362. PMID: 33434690(https://pubmed.ncbi.nlm.nih/33434690/)
• Wu D et al. (2022) ROCK2 in neuroinflammation. J Neuroinflammation 19(1):33. PMID: 35086534(https://pubmed.ncbi.nlm.nih/35086534/)
• Hensel N et al. (2019) ROCK and ALS. Acta Neuropathol 138(1):55-72. PMID: 30972427(https://pubmed.ncbi.nlm.nih/30972427/)

See Also

• [RhoA Protein](/proteins/)
• [MLCK](/proteins/)
• [Cytoskeleton](/proteins/)

External Links

• [UniProt: O75116](https://www.uniprot.org/uniprot/O75116)
• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)