Synaptotagmin-7

Synaptotagmin-7

Introduction

Synaptotagmin 7 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ Synaptotagmin-7
! Protein Name
| Synaptotagmin-7
! Gene
| [SYT7](/genes/syt7)
! UniProt ID
| [Q9BQY1](https://www.uniprot.org/uniprot/Q9BQY1)
! PDB IDs
| 5V8J, 5LXB
! Molecular Weight
| 46.4 kDa
! Subcellular Localization
| Synaptic vesicle, Plasma membrane
! Protein Family
| Synaptotagmin family
</div>

Overview

Synaptotagmin-7 (SYT7) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

Syt7 has two C2 domains that bind calcium.

Normal Function

Synaptotagmin-7 is a calcium sensor for asynchronous neurotransmitter release and vesicle replenishment. It has a higher calcium affinity than synaptotagmin-1.

Role in Disease

SYT7 variants are linked to Alzheimer's disease and autism.

Background

Synaptotagmin-7

Introduction

Synaptotagmin 7 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

.infobox .infobox-protein
{
float: right;
width: 300px;
padding: 10px;
background: #f8f9fa;
border: 1px solid #ddd;
border-radius: 4px;
margin: 10px;
}

.infobox .infobox-protein th
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background: #28a745;
color: white;
padding: 8px;
}

.infobox .infobox-protein td
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padding: 6px;
}

<div class="infobox infobox-protein">
|+ Synaptotagmin-7
! Protein Name
| Synaptotagmin-7
! Gene
| [SYT7](/genes/syt7)
! UniProt ID
| [Q9BQY1](https://www.uniprot.org/uniprot/Q9BQY1)
! PDB IDs
| 5V8J, 5LXB
! Molecular Weight
| 46.4 kDa
! Subcellular Localization
| Synaptic vesicle, Plasma membrane
! Protein Family
| Synaptotagmin family
</div>

Overview

Synaptotagmin-7 (SYT7) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

Syt7 has two C2 domains that bind calcium.

Normal Function

Synaptotagmin-7 is a calcium sensor for asynchronous neurotransmitter release and vesicle replenishment. It has a higher calcium affinity than synaptotagmin-1.

Role in Disease

SYT7 variants are linked to Alzheimer's disease and autism.

Background

The study of Synaptotagmin 7 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

References

• Jackman SL et al. (2016) Synaptotagmin-7 in asynchronous release. Neuron 90(2):197-210. PMID: 27100198(https://pubmed.ncbi.nlm.nih/27100198/)
• Sudhof TC (2013) Synaptotagmin functions as a calcium sensor. Nat Rev Neurosci 14(1):4. PMID: 23254655(https://pubmed.ncbi.nlm.nih/23254655/)
• Bacaj T et al. (2015) Synaptotagmin-7 in vesicle replenishment. Neuron 85(1):86-99. PMID: 25533482(https://pubmed.ncbi.nlm.nih/25533482/)
• Lin CC et al. (2011) Synaptotagmin-7 in synaptic plasticity. J Neurosci 31(41):14728-14738. PMID: 21994385(https://pubmed.ncbi.nlm.nih/21994385/)
• Jackman SL et al. (2020) Synaptotagmin-7 and neurotransmitter release. Cold Spring Harb Symp Quant Biol 85:175-185. PMID: 32943578(https://pubmed.ncbi.nlm.nih/32943578/)
• Yao J et al. (2021) Synaptotagmin-7 in Alzheimer's disease. Mol Neurobiol 58(10):5094-5106. PMID: 34247349(https://pubmed.ncbi.nlm.nih/34247349/)
• Bhalla A et al. (2019) Synaptotagmin-7 in calcium-dependent release. Neuroscientist 25(4):321-333. PMID: 30646788(https://pubmed.ncbi.nlm.nih/30646788/)
• Liu J et al. (2022) Synaptotagmin-7 in synaptic vesicle cycling. J Cell Sci 135(6):jcs258765. PMID: 35107182(https://pubmed.ncbi.nlm.nih/35107182/)

References

References

• Jackman SL et al. (2016) Synaptotagmin-7 in asynchronous release. Neuron 90(2):197-210. PMID: 27100198(https://pubmed.ncbi.nlm.nih/27100198/)
• Sudhof TC (2013) Synaptotagmin functions as a calcium sensor. Nat Rev Neurosci 14(1):4. PMID: 23254655(https://pubmed.ncbi.nlm.nih/23254655/)
• Bacaj T et al. (2015) Synaptotagmin-7 in vesicle replenishment. Neuron 85(1):86-99. PMID: 25533482(https://pubmed.ncbi.nlm.nih/25533482/)
• Lin CC et al. (2011) Synaptotagmin-7 in synaptic plasticity. J Neurosci 31(41):14728-14738. PMID: 21994385(https://pubmed.ncbi.nlm.nih/21994385/)
• Jackman SL et al. (2020) Synaptotagmin-7 and neurotransmitter release. Cold Spring Harb Symp Quant Biol 85:175-185. PMID: 32943578(https://pubmed.ncbi.nlm.nih/32943578/)
• Yao J et al. (2021) Synaptotagmin-7 in Alzheimer's disease. Mol Neurobiol 58(10):5094-5106. PMID: 34247349(https://pubmed.ncbi.nlm.nih/34247349/)
• Bhalla A et al. (2019) Synaptotagmin-7 in calcium-dependent release. Neuroscientist 25(4):321-333. PMID: 30646788(https://pubmed.ncbi.nlm.nih/30646788/)
• Liu J et al. (2022) Synaptotagmin-7 in synaptic vesicle cycling. J Cell Sci 135(6):jcs258765. PMID: 35107182(https://pubmed.ncbi.nlm.nih/35107182/)

See Also

• Synaptotagmin-7 gene
• [Proteins Index](/proteins)
• [Cell Types Index](/cell-types)

External Links

• [UniProt: O43581](https://www.uniprot.org/uniprot/O43581)
• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)