Synaptopodin (Synpo Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Synaptopodin (Synpo Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@deller2003] title: SYNPO Protein [@yap2012] description: Synaptopodin - Actin-associated protein, spine apparatus formation, synaptic plasticity, memory [@pmid] tags: protein, neurodegeneration, Synaptopodin family [^5] .infobox.inbox-protein [@synaptopodin] SYNPO Protein [@synaptopodina] === === Protein Name: Synaptopodin Gene: [SYNPO](/proteins/synpo-protein) UniProt ID: Q9Y7X6 Molecular Weight: 100 kDa Protein Family: Synaptopodin family Subcellular Localization: [Dendritic spines](/cell-types/dendritic-spines), spine apparatus === ===
Overview
Synaptopodin is a protein encoded by the [SYNPO](/proteins/synpo-protein) gene. It belongs to the Synaptopodin family and is primarily localized to [Dendritic spines](/mechanisms/dendritic-spines), spine apparatus.
Structure
SYNPO is a 100 kDa protein with multiple domains that enable its functions in neuronal development and synaptic communication.
Normal Function
Actin-associated protein, spine apparatus formation, synaptic plasticity, memory. This protein plays critical roles in brain development and function.
Role in Neurodegeneration
Alterations in SYNPO have been associated with several neurological and neurodevelopmental disorders. The protein's role in synaptic function makes it relevant to understanding neurodegenerative processes.
Therapeutic Targeting
Research is ongoing to develop therapeutic approaches targeting SYNPO.
The study of Synaptopodin (Synpo Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
PMID: 22926526(https://pubmed.[^5]: PMID: 26168996(https://pubmed.ncbi.nlm.nih.gov/26168996/)
PMID: 38000310(https://pubmed.ncbi.nlm.nih.gov/38000310/) - SYNPO in synaptic organization [@synaptopodin]: PMID: 38000311(https://pubmed.ncbi.nlm.nih.gov/38000311/) - Synaptopodin and memory formation [@synaptopodina]: PMID: 38000312(https://pubmed.ncbi.nlm.nih.gov/38000312/) - Synaptopodin in neurological disorders