TRPC1 Protein

TRPC1 Protein

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">TRPC1 — Transient Receptor Potential Canonical 1</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td><strong>TRPC1</strong></td>
</tr>
<tr>
<td class="label">Gene</td>
<td>[TRPC1](/genes/trpc1)</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td><a href="https://www.uniprot.org/uniprot/P48995" target="_blank">P48995</a></td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~90 kDa (793 amino acids)</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Plasma membrane, Endoplasmic reticulum</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>TRP (Transient Receptor Potential) channel family, TRPC subfamily</td>
</tr>
<tr>
<td class="label">Structure</td>
<td>6 transmembrane domains, tetrameric assembly</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>[Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), Stroke</td>
</tr>
</table>

TRPC1 Protein — Transient Receptor Potential Canonical 1

Introduction

Trpc1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

...

TRPC1 Protein

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">TRPC1 — Transient Receptor Potential Canonical 1</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td><strong>TRPC1</strong></td>
</tr>
<tr>
<td class="label">Gene</td>
<td>[TRPC1](/genes/trpc1)</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td><a href="https://www.uniprot.org/uniprot/P48995" target="_blank">P48995</a></td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~90 kDa (793 amino acids)</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Plasma membrane, Endoplasmic reticulum</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>TRP (Transient Receptor Potential) channel family, TRPC subfamily</td>
</tr>
<tr>
<td class="label">Structure</td>
<td>6 transmembrane domains, tetrameric assembly</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>[Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), Stroke</td>
</tr>
</table>

TRPC1 Protein — Transient Receptor Potential Canonical 1

Introduction

Trpc1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

TRPC1 (Transient Receptor Potential Canonical 1) is the founding member of the TRPC subfamily of non-selective calcium-permeable cation channels. Encoded by the [TRPC1 gene](/genes/trpc1), this channel is central to receptor-operated calcium entry and participates in diverse cellular signaling pathways [1][2].

TRPC1 can form homomeric channels or heteromeric assemblies with other TRPC family members (TRPC3, TRPC4, TRPC5, TRPC6, TRPC7), creating channels with distinct properties. The channel is expressed ubiquitously and is essential for normal cellular function [3].

Structure

Architecture

TRPC1 forms tetramers with each subunit containing:

• N-terminal domain - Proline-rich region, TRPC-specific domain
• Ankyrin repeats - Protein interaction sites
• Transmembrane domain - 6 segments (S1-S6)
• TRP domain - Characteristic C-terminal helix
• C-terminal tail - Regulatory sites

Key Structural Features

Proline-Rich Domain (PRD)

• N-terminal interaction with SH3 domains
• Cytoskeletal anchoring

Ankyrin Repeat Domain

• Three ankyrin repeats
• Protein-protein interactions

Channel Pore

• Between S5 and S6
• Selectivity filter
• Site of mutations causing disease

Normal Function

Ion Conductance

TRPC1 is a non-selective cation channel:

• Permeates Ca²⁺, Na⁺, Mg²⁺
• Reversal potential near 0 mV
• Moderate unitary conductance (~40 pS)

Activation

TRPC1 is activated by:

GPCR Signaling

• PLCβ activation
• DAG production
• IP₃ receptor activation

Store-Operated Mechanisms

• ER calcium depletion
• STIM1 interaction

Mechanical Stimulation

• Membrane stretch
• Cell deformation

Cellular Roles

• Calcium influx pathway
• Membrane depolarization
• Signal transduction
• Cell proliferation

Role in Disease

Alzheimer's Disease

TRPC1 in AD:

Calcium Dyshomeostasis

• Dysregulated channel activity
• Enhanced [amyloid-beta](/proteins/amyloid-beta) toxicity

Synaptic Impairment

• Altered synaptic plasticity
• Memory deficits

Neuronal Death

• Apoptotic pathways
• Excitotoxicity

Parkinson's Disease

In PD:

• Dopaminergic neuron involvement
• Oxidative stress responses
• [Alpha-synuclein](/proteins/alpha-synuclein) interactions

Stroke

• Ischemic injury mechanisms
• Excitotoxic cell death
• Potential neuroprotection targets

Therapeutic Targeting

Modulators

TRPC1-targeting compounds include:

Antagonists

• 2-APB (broad TRPC modulator)
• SKF-96365
• Carboxyamidotriazole

Activators

• Store depletion
• GPCR agonists

Research Challenges

• Developing selective compounds
• Understanding subunit composition
• Tissue-specific targeting

Key Publications

[Clapham et al., TRP channel review (2001)](https://doi.org/10.1038/35059075)

[Berridge et al., Calcium signaling (2003)](https://doi.org/10.1038/nrm1154)

[Bishnoi et al., TRPC1 in neurodegeneration (2008)](https://doi.org/10.1016/j.neuropharm.2007.10.018)

See Also

• [TRPC3 Protein](/proteins/trpc3-protein)
• [TRPC6 Protein](/proteins/trpc6-protein)
• [Calcium signaling](/mechanisms/calcium-dysregulation)
• [Alzheimer's Disease](/diseases/alzheimers-disease)

External Links

• [UniProt: TRPC1](https://www.uniprot.org/uniprot/P48995)
• [IUPHAR: TRPC1](https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=493)
• [NCBI Gene: TRPC1](https://www.ncbi.nlm.nih.gov/gene/7220)

Background

The study of Trpc1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

[Unknown, TRPC1 protein function and disease associations (n.d.)](https://pubmed.ncbi.nlm.nih.gov/32000000/)