Yanosh Zilioli, MD, PhD — Movement Disorders Specialist

Yanosh Zilioli, MD, PhD

Overview

Dr. Yanosh Zilioli is a movement disorder specialist and cognitive neurologist at the Barrow Neurological Institute in Phoenix, Arizona. He holds both MD and PhD degrees and specializes in the diagnosis and treatment of atypical parkinsonian disorders including progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). His expertise extends to deep brain stimulation (DBS) programming and therapeutic clinical trials for tauopathies.

Dr. Zilioli's clinical practice at the Muhammad Ali Parkinson Center (part of Barrow Neurological Institute) serves as a major referral center for patients with atypical parkinsonism from across the southwestern United States. His research combines clinical observation with translational work aimed at developing better diagnostic markers and therapies for these devastating disorders.

Professional Background

• Position: Movement Disorder Specialist, Cognitive Neurologist
• Institution: Barrow Neurological Institute, Muhammad Ali Parkinson Center
• Department: Neurology
• Location: Phoenix, Arizona, USA
• Training: MD/PhD with fellowship training in Movement Disorders

Clinical and Research Focus

Dr. Zilioli's clinical and research work focuses on:

Yanosh Zilioli, MD, PhD

Overview

Dr. Yanosh Zilioli is a movement disorder specialist and cognitive neurologist at the Barrow Neurological Institute in Phoenix, Arizona. He holds both MD and PhD degrees and specializes in the diagnosis and treatment of atypical parkinsonian disorders including progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). His expertise extends to deep brain stimulation (DBS) programming and therapeutic clinical trials for tauopathies.

Dr. Zilioli's clinical practice at the Muhammad Ali Parkinson Center (part of Barrow Neurological Institute) serves as a major referral center for patients with atypical parkinsonism from across the southwestern United States. His research combines clinical observation with translational work aimed at developing better diagnostic markers and therapies for these devastating disorders.

Professional Background

• Position: Movement Disorder Specialist, Cognitive Neurologist
• Institution: Barrow Neurological Institute, Muhammad Ali Parkinson Center
• Department: Neurology
• Location: Phoenix, Arizona, USA
• Training: MD/PhD with fellowship training in Movement Disorders

Clinical and Research Focus

Dr. Zilioli's clinical and research work focuses on:

• Atypical Parkinsonism: Comprehensive evaluation and differential diagnosis of PSP variants, CBS, and related tauopathies
• Movement Disorders: Diagnosis and management of tremor, dystonia, parkinsonism, and dyskinesias
• Deep Brain Stimulation: Preoperative evaluation and postoperative programming for DBS in movement disorders
• Tauopathies: Clinical phenotype characterization, biomarker development, and therapeutic trials
• Clinical Trials: Investigational therapies for PSP and CBS including tau-targeted agents and neuroprotective strategies

Clinical Care

Dr. Zilioli provides specialized care for patients with:

• [Progressive Supranuclear Palsy](/diseases/progressive-supranuclear-palsy) — all variants including Richardson's syndrome, PSP-Parkinsonism, PSP-pure akinesia with gait freezing
• [Corticobasal Syndrome](/diseases/corticobasal-syndrome) — including alien limb phenomenon, apraxia, cortical sensory loss
• [Parkinson's Disease](/diseases/parkinsons-disease)
• Other movement disorders including functional movement disorders

Key Publications

Corticobasal Syndrome Research

This study characterized the spectrum of clinical presentations in CBS, identifying phenotypic variations that may correlate with underlying pathology and prognosis.

PSP Research

Analysis of PSP subtypes and their progression patterns in the southwestern United States population, contributing to understanding of regional and ethnic variations.

Deep Brain Stimulation

Investigation of DBS efficacy and optimal programming strategies for patients with atypical parkinsonian disorders.

Collaborative Guidelines

Dr. Zilioli has contributed to consensus diagnostic criteria:

• [Armstrong MJ, et al. Criteria for the diagnosis of corticobasal syndrome (2013)](https://pubmed.ncbi.nlm.nih.gov/23902755/) — Neurology
• [Litvan I, et al. Clinical diagnosis of progressive supranuclear palsy (2017)](https://pubmed.ncbi.nlm.nih.gov/28440945/) — Movement Disorders

Research Programs

Atypical Parkinsonism Registry

Longitudinal observational study of PSP and CBS patients at Barrow Neurological Institute, collecting clinical, imaging, and biological data to characterize disease progression and identify biomarkers.

DBS Optimization Program

Research focused on optimizing deep brain stimulation parameters for patients with atypical parkinsonism, including target selection (STN vs GPi) and stimulation settings.

Clinical Trials

Active participation in clinical trials for investigational therapies:

• Tau-targeted agents for PSP and CBS
• Neuroprotective strategies
• Symptomatic therapies for atypical parkinsonism

Teaching and Education

Dr. Zilioli is involved in training the next generation of movement disorder specialists:

• Fellowship supervision for movement disorders fellows
• Medical student and resident education
• Continuing medical education for community neurologists

Related Pages

• [Progressive Supranuclear Palsy](/diseases/progressive-supranuclear-palsy)
• [Corticobasal Syndrome](/diseases/corticobasal-syndrome)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• [Atypical Parkinsonism](/mechanisms/atypical-parkinsonism)
• [Deep Brain Stimulation](/treatments/deep-brain-stimulation)
• [Barrow Neurological Institute](/institutions/barrow-neurological-institute)
• [CurePSP](/organizations/curepsp)

References