🧫
Microglial Contributions to Huntington's Disease Pathogenesis
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-microgli
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.908070Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['HD'], 'diseases': ['Neuroinflammation']} |
| model_system | human |
| summary | # Microglial Contributions to Huntington's Disease Pathogenesis ## Background and Rationale Microglial dysfunction represents a critical but understudied component of Huntington's disease pathogenesis |
| replication_status | replicated |
| methodology_notes | **Phase 1: Patient Recruitment and Sample Collection (Months 1-6)** • Recruit 120 participants: 40 HD patients (early stage, CAG 40-50 repeats), 40 HD patients (advanced stage, CAG >50 repeats), 40 ag |
| primary_outcome | Validate Microglial Contributions to Huntington's Disease Pathogenesis |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.908076'} |
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