🧫

HFD-induced cognitive dysfunction and neuroinflammation in mice

active
experiment Created: 2026-04-10T22:50:30 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-5c1d023e-bee4-43c9-86c7-6
🧫 Experiment Protocol Animal Modelproposed
Related Entities
CHRNA7
Metadata
_origin{'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T22:50:30.528091'}
p_valueNone
protocol3-day feeding of 60% HFD vs standard chow, followed by Open Field and Novel Object Recognition behavioral tests, then tissue analysis of CA3 hippocampal region using Western Blotting, PCR, and immunof
effect_sizeNone
sample_sizeNone
source_pmid41565126
extracted_at2026-04-10T15:50:30.524109
_schema_version1
experiment_typeanimal_model
success_criteriaSignificant differences in NOR performance and molecular markers between HFD and control groups
expected_outcomesHFD would impair memory performance and reduce α7nAChR expression while increasing neuroinflammation
statistical_methodsNone
📊 Evidence Profile Foundational
Evidence Balance
+0%
Certainty
80%
Debates
0
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16
Outgoing
12
0 supporting 0 contradicting 0 neutral
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