gene

CHRNA7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRNA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

407Connections
2Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

CHRNA7 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Aging, Als, Inflammation. Connected to 37 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCHRNA7
Chromosome15q13.3
Protein TypeChannel
Target ClassProtein
FunctionThe nicotinic acetylcholine receptor alpha 7 (α7 nAChR) is a homomeric ligand-gated ion channel highly expressed in the brain, particularly in the hippocampus, cortex, and basal ganglia.
Mechanism of ActionPrioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication
Primary Expressionthe brain, particularly in the hippocampus, cortex, and basal ganglia
DruggabilityMedium (0.50)
Clinical StagePhase II
Amino Acids502 aa
Exons10
PathwaysNF-κB, MAPK
Ensembl IDENSG00000175344
GeneCardsCHRNA7
Human Protein AtlasCHRNA7
Associated DiseasesALS, Alzheimer, COLORECTAL CANCER, DNA METHYLATION, INFLAMMATION
Known Drugs/Compoundsvalproic acid
InteractionsNLRP3, PI3K, JAK2, PICK1, ERK1, YAP1
SciDEX TargetView Target Profile
SciDEX HypothesesEnhancing Vagal Cholinergic Signaling to Restore G
Cholinergic Attention Modulation Hypothesis
KG Connections407 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CHRNA7 Gene

gene · 978 words

Ion Channel Dysfunction in Alzheimer's Disease

mechanism · 3308 words

CHRNB3 Gene

gene · 2904 words

NfL-Guided Neuroprotection Threshold

idea · 2577 words

Cholinergic Basal Forebrain Neurons in Alzheimer's Disease

cell · 2495 words

Cholinergic System Dysfunction in Neurodegeneration

mechanism · 2382 words

Pathway Diagram

graph TD
    CHRNA7["<b>CHRNA7</b>"]
    Inflammation{"Inflammation"}
    CHRNA7 -->|"activates"| Inflammation
    Aging{"Aging"}
    CHRNA7 -->|"activates"| Aging
    Ms{"Ms"}
    CHRNA7 -->|"activates"| Ms
    Als{"Als"}
    CHRNA7 -->|"associated with"| Als
    Schizophrenia{"Schizophrenia"}
    CHRNA7 -->|"associated with"| Schizophrenia
    SYT1["SYT1"]
    CHRNA7 -->|"regulates"| SYT1
    STAT3["STAT3"]
    CHRNA7 -->|"regulates"| STAT3
    HMOX1["HMOX1"]
    CHRNA7 -->|"regulates"| HMOX1
    TRPV1["TRPV1"]
    CHRNA7 -->|"regulates"| TRPV1
    P2RY2["P2RY2"]
    CHRNA7 -->|"regulates"| P2RY2
    FOXP3["FOXP3"]
    CHRNA7 -->|"regulates"| FOXP3
    TPH2["TPH2"]
    CHRNA7 -->|"regulates"| TPH2
    CHAT["CHAT"]
    CHAT -->|"co expressed with"| CHRNA7
    CHAT -->|"regulates"| CHRNA7
    PANX1["PANX1"]
    PANX1 -->|"regulates"| CHRNA7
    S100B["S100B"]
    S100B -->|"regulates"| CHRNA7
    RELB["RELB"]
    RELB -->|"regulates"| CHRNA7
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| CHRNA7
    CASP3["CASP3"]
    CASP3 -->|"regulates"| CHRNA7
    SOCS3["SOCS3"]
    SOCS3 -->|"regulates"| CHRNA7
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| CHRNA7
    GENES["GENES"]
    GENES -->|"regulates"| CHRNA7
    CXCL2["CXCL2"]
    CXCL2 -->|"regulates"| CHRNA7
    SNAP25["SNAP25"]
    SNAP25 -->|"regulates"| CHRNA7
    style CHRNA7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (275)

TargetRelationTypeStr
ds-6784494f1741provides_data_fordataset1.00
ACETYLCHOLINEreceptor_forneurotransmitter0.95
CHOLINERGIC_ANTI_INFLAMMATORY_PATHWAYmediatespathway0.90
VAGUS_NERVEeffector_ofnerve0.90
MACROPHAGEexpressed_oncell_type0.90

Incoming (132)

SourceRelationTypeStr
ds-6784494f1741data_indataset1.00
h-a4e259e0targets_genehypothesis0.90
h-1e2405e1targets_genehypothesis0.90
hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-3targets_genehypothesis0.90
VAGUS_NERVE_STIMULATIONsignaling_requirestherapy0.85

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A 0.512 neurodegeneration What are the mechanisms by which gut mic
Cholinergic Attention Modulation Hypothesis 0.397 methodology Unable to extract research questions - t

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] Teng T, Yang S, Li J, Wang H, Wu F, He Y Neurobiology of disease 2026 0
Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] Saihati HAA, Ahmed BY, Mosaad RM, El-Gar Molecular nutrition & food res 2026 0
Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] Gholizadeh F, Hajiaghayi M, Rahbari N, C Eur J Immunol 2026 0
Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982] Nguyen DT, Mendoza K, Hall C, Tan C, Cha Experimental neurology 2026 0
Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755] Mobasher M, Hone AJ, Pilzecker M, Bozic Frontiers in immunology 2026 0
Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126] Costa SO, Silva IM, Chaves WF, Esteves A The Journal of nutritional bio 2026 0
Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625] Cho Y, Kim HG, Kang JH, Oh ET, Park HJ International journal of biolo 2026 0
Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703] Feng X, Jia M, Cai M, Zhu T, Hashimoto K Molecular psychiatry 2025 0
The ATP-mediated cytokine release by macrophages is down-modulated by unconventi [PMID:41221292] Wolf PMK, Hanke D, Singh VK, Keller HL, Frontiers in immunology 2025 0
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] Xia XM, Duan Y, Wang YP, Han RX, Dong YF Acta Pharmacol Sin 2024 0
Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-o [PMID:38944290] ["Yang Y", "Eguchi A", "Mori C", "Hashim Journal of affective disorders 2024 0
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] Xia XM, Duan Y, Wang YP, Han RX, Dong YF Acta pharmacologica Sinica 2024 0
A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depressi [PMID:36191806] ["Yang Y", "Eguchi A", "Wan X", "Chang L Progress in neuro-psychopharma 2023 0
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoies [PMID:35352063] Schloss MJ, Hulsmans M, Rohde D, Lee IH, Nat Immunol 2022 0
Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to [PMID:36077246] Newell-Rogers MK, Duong A, Nazarali R, T International journal of molec 2022 0
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] Lieberwirth JK, Joset P, Heinze A, Hents European journal of human gene 2021 0
Vagus Nerve Stimulation and the Cardiovascular System. [PMID:31109966] Capilupi MJ, Kerath SM, Becker LB Cold Spring Harbor perspective 2020 0
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174] Liu J, Xie J International journal of envir 2020 0
Microglial memory of early life stress and inflammation: Susceptibility to neuro [PMID:31703966] Desplats P, Gutierrez AM, Antonelli MC, Neuroscience and biobehavioral 2020 0
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582] Karas M, Marinsek N, Goldhahn J, Foschin Digital biomarkers 2020 0