Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHRNA7 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Aging, Als, Inflammation. Connected to 37 entities in the SciDEX knowledge graph.
| Gene Symbol | CHRNA7 |
| Chromosome | 15q13.3 |
| Protein Type | Channel |
| Target Class | Protein |
| Function | The nicotinic acetylcholine receptor alpha 7 (α7 nAChR) is a homomeric ligand-gated ion channel highly expressed in the brain, particularly in the hippocampus, cortex, and basal ganglia. |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication |
| Primary Expression | the brain, particularly in the hippocampus, cortex, and basal ganglia |
| Druggability | Medium (0.50) |
| Clinical Stage | Phase II |
| Amino Acids | 502 aa |
| Exons | 10 |
| Pathways | NF-κB, MAPK |
| Ensembl ID | ENSG00000175344 |
| GeneCards | CHRNA7 |
| Human Protein Atlas | CHRNA7 |
| Associated Diseases | ALS, Alzheimer, COLORECTAL CANCER, DNA METHYLATION, INFLAMMATION |
| Known Drugs/Compounds | valproic acid |
| Interactions | NLRP3, PI3K, JAK2, PICK1, ERK1, YAP1 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Enhancing Vagal Cholinergic Signaling to Restore G Cholinergic Attention Modulation Hypothesis |
| KG Connections | 407 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNA7["<b>CHRNA7</b>"]
Inflammation{"Inflammation"}
CHRNA7 -->|"activates"| Inflammation
Aging{"Aging"}
CHRNA7 -->|"activates"| Aging
Ms{"Ms"}
CHRNA7 -->|"activates"| Ms
Als{"Als"}
CHRNA7 -->|"associated with"| Als
Schizophrenia{"Schizophrenia"}
CHRNA7 -->|"associated with"| Schizophrenia
SYT1["SYT1"]
CHRNA7 -->|"regulates"| SYT1
STAT3["STAT3"]
CHRNA7 -->|"regulates"| STAT3
HMOX1["HMOX1"]
CHRNA7 -->|"regulates"| HMOX1
TRPV1["TRPV1"]
CHRNA7 -->|"regulates"| TRPV1
P2RY2["P2RY2"]
CHRNA7 -->|"regulates"| P2RY2
FOXP3["FOXP3"]
CHRNA7 -->|"regulates"| FOXP3
TPH2["TPH2"]
CHRNA7 -->|"regulates"| TPH2
CHAT["CHAT"]
CHAT -->|"co expressed with"| CHRNA7
CHAT -->|"regulates"| CHRNA7
PANX1["PANX1"]
PANX1 -->|"regulates"| CHRNA7
S100B["S100B"]
S100B -->|"regulates"| CHRNA7
RELB["RELB"]
RELB -->|"regulates"| CHRNA7
P2RY1["P2RY1"]
P2RY1 -->|"regulates"| CHRNA7
CASP3["CASP3"]
CASP3 -->|"regulates"| CHRNA7
SOCS3["SOCS3"]
SOCS3 -->|"regulates"| CHRNA7
TRPA1["TRPA1"]
TRPA1 -->|"regulates"| CHRNA7
GENES["GENES"]
GENES -->|"regulates"| CHRNA7
CXCL2["CXCL2"]
CXCL2 -->|"regulates"| CHRNA7
SNAP25["SNAP25"]
SNAP25 -->|"regulates"| CHRNA7
style CHRNA7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-6784494f1741 | provides_data_for | dataset | 1.00 |
| ACETYLCHOLINE | receptor_for | neurotransmitter | 0.95 |
| CHOLINERGIC_ANTI_INFLAMMATORY_PATHWAY | mediates | pathway | 0.90 |
| VAGUS_NERVE | effector_of | nerve | 0.90 |
| MACROPHAGE | expressed_on | cell_type | 0.90 |
| TNF_ALPHA | suppresses | cytokine | 0.85 |
| IL1_BETA | suppresses | cytokine | 0.85 |
| GTS-21 | agonized_by | drug | 0.85 |
| MICROGLIA | expressed_on | cell_type | 0.85 |
| PNU-282987 | agonized_by | drug | 0.80 |
| nicotinic receptor | expressed_in | receptor | 0.80 |
| neurons | expressed_in | cell_type | 0.80 |
| NLRP3 | inhibits | protein | 0.75 |
| PARKINSON'S DISEASE | protective_against | disease | 0.75 |
| HEART_RATE_VARIABILITY | correlates_with | biomarker | 0.70 |
| schizophrenia | associated_with | disease | 0.70 |
| nicotinic receptor | implicated_in | receptor | 0.70 |
| DONEPEZIL | indirectly_activated_by | drug | 0.70 |
| cortex | expressed_in | brain_region | 0.70 |
| neurons | regulates | cell_type | 0.70 |
| neural stem cells | regulates | cell_type | 0.70 |
| neurodegeneration | associated_with | disease | 0.66 |
| VALPROATE | regulates | drug | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Dementia | protects_against | disease | 0.65 |
| Depression | expressed_in | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Vascular Dementia | transports | disease | 0.65 |
| Alzheimer | transports | disease | 0.65 |
| Dementia | transports | disease | 0.65 |
| ALS | transports | disease | 0.65 |
| Frontotemporal Dementia | transports | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Bipolar | activates | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-6784494f1741 | data_in | dataset | 1.00 |
| h-a4e259e0 | targets_gene | hypothesis | 0.90 |
| h-1e2405e1 | targets_gene | hypothesis | 0.90 |
| hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-3 | targets_gene | hypothesis | 0.90 |
| VAGUS_NERVE_STIMULATION | signaling_requires | therapy | 0.85 |
| Vagus Nerve Stimulation | upregulates | process | 0.85 |
| CHAT | co_expressed_with | gene | 0.80 |
| CHAT | regulates | gene | 0.70 |
| CHRFAM7A | associated_with | gene | 0.70 |
| CHRFAM7A | inhibits | gene | 0.70 |
| CHRFAM7A | expressed_in | gene | 0.70 |
| NEUROBLASTOMA | protects_against | disease | 0.65 |
| PANX1 | regulates | gene | 0.60 |
| S100B | regulates | gene | 0.60 |
| RELB | regulates | gene | 0.60 |
| P2RY1 | regulates | gene | 0.60 |
| CASP3 | regulates | gene | 0.60 |
| SOCS3 | regulates | gene | 0.60 |
| TRPA1 | regulates | gene | 0.60 |
| CXCL2 | regulates | gene | 0.60 |
| SNAP25 | regulates | gene | 0.60 |
| P2RX7 | regulates | gene | 0.60 |
| SYT2 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| SOD2 | regulates | gene | 0.60 |
| NOS2 | regulates | gene | 0.60 |
| P2RX3 | regulates | gene | 0.60 |
| RELA | regulates | gene | 0.60 |
| SYP | regulates | gene | 0.60 |
| NRXN1 | associated_with | gene | 0.60 |
| CHAT | therapeutic_target | gene | 0.60 |
| CYP3A4 | therapeutic_target | gene | 0.60 |
| APOE | therapeutic_target | gene | 0.60 |
| CYP2D6 | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| ACE | therapeutic_target | gene | 0.60 |
| AKT | inhibits | gene | 0.60 |
| PICK1 | interacts_with | gene | 0.60 |
| JAK2 | interacts_with | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| SOX2 | expressed_in | gene | 0.60 |
| YAP1 | activates | gene | 0.60 |
| APOE | inhibits | gene | 0.60 |
| PPAR | transports | gene | 0.60 |
| APOE | transports | gene | 0.60 |
| ABCB1 | transports | gene | 0.60 |
| CHAT | transports | gene | 0.60 |
| ACE | transports | gene | 0.60 |
| BCHE | transports | gene | 0.60 |
| PPAR | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A | 0.512 | neurodegeneration | What are the mechanisms by which gut mic |
| Cholinergic Attention Modulation Hypothesis | 0.397 | methodology | Unable to extract research questions - t |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] | Teng T, Yang S, Li J, Wang H, Wu F, He Y | Neurobiology of disease | 2026 | 0 |
| Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] | Saihati HAA, Ahmed BY, Mosaad RM, El-Gar | Molecular nutrition & food res | 2026 | 0 |
| Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] | Gholizadeh F, Hajiaghayi M, Rahbari N, C | Eur J Immunol | 2026 | 0 |
| Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982] | Nguyen DT, Mendoza K, Hall C, Tan C, Cha | Experimental neurology | 2026 | 0 |
| Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755] | Mobasher M, Hone AJ, Pilzecker M, Bozic | Frontiers in immunology | 2026 | 0 |
| Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126] | Costa SO, Silva IM, Chaves WF, Esteves A | The Journal of nutritional bio | 2026 | 0 |
| Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625] | Cho Y, Kim HG, Kang JH, Oh ET, Park HJ | International journal of biolo | 2026 | 0 |
| Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703] | Feng X, Jia M, Cai M, Zhu T, Hashimoto K | Molecular psychiatry | 2025 | 0 |
| The ATP-mediated cytokine release by macrophages is down-modulated by unconventi [PMID:41221292] | Wolf PMK, Hanke D, Singh VK, Keller HL, | Frontiers in immunology | 2025 | 0 |
| Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] | Xia XM, Duan Y, Wang YP, Han RX, Dong YF | Acta Pharmacol Sin | 2024 | 0 |
| Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-o [PMID:38944290] | ["Yang Y", "Eguchi A", "Mori C", "Hashim | Journal of affective disorders | 2024 | 0 |
| Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] | Xia XM, Duan Y, Wang YP, Han RX, Dong YF | Acta pharmacologica Sinica | 2024 | 0 |
| A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depressi [PMID:36191806] | ["Yang Y", "Eguchi A", "Wan X", "Chang L | Progress in neuro-psychopharma | 2023 | 0 |
| B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoies [PMID:35352063] | Schloss MJ, Hulsmans M, Rohde D, Lee IH, | Nat Immunol | 2022 | 0 |
| Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to [PMID:36077246] | Newell-Rogers MK, Duong A, Nazarali R, T | International journal of molec | 2022 | 0 |
| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] | Lieberwirth JK, Joset P, Heinze A, Hents | European journal of human gene | 2021 | 0 |
| Vagus Nerve Stimulation and the Cardiovascular System. [PMID:31109966] | Capilupi MJ, Kerath SM, Becker LB | Cold Spring Harbor perspective | 2020 | 0 |
| Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174] | Liu J, Xie J | International journal of envir | 2020 | 0 |
| Microglial memory of early life stress and inflammation: Susceptibility to neuro [PMID:31703966] | Desplats P, Gutierrez AM, Antonelli MC, | Neuroscience and biobehavioral | 2020 | 0 |
| Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582] | Karas M, Marinsek N, Goldhahn J, Foschin | Digital biomarkers | 2020 | 0 |