Cell-state stratification is required to resolve m6A RNA Modification and Alpha-Synuclein Aggregation in Substantia Nigra

graph TD
    m6A_modification["m6A modification"] -->|associated with| Parkinson_s_disease["Parkinson's disease"]
    m6A_modification_1["m6A modification"] -->|regulates| alpha_synuclein_transcrip["alpha-synuclein transcript fate"]
    m6A_modification_2["m6A modification"] -->|modulates| alpha_synuclein_aggregati["alpha-synuclein aggregation kinetics"]
    m6A_writers_erasers_reade["m6A writers/erasers/readers"] -->|regulates| alpha_synuclein_biology["alpha-synuclein biology"]
    dopaminergic_neuron_pertu["dopaminergic neuron perturbation"] -->|causes| m6A_mediated_alpha_synucl["m6A-mediated alpha-synuclein effects"]
    alpha_synuclein_aggregati_3["alpha-synuclein aggregation"] -->|causes| neurodegeneration_in_Subs["neurodegeneration in Substantia Nigra"]
    cell_state_stratification["cell-state stratification"] -->|preserves| causal_subpopulation_effe["causal subpopulation effects"]
    m6A_manipulation["m6A manipulation"] -->|causes| broad_toxicity["broad toxicity"]
    m6A_RNA_modification["m6A RNA modification"] -->|modulates| Lewy_body_like_aggregatio["Lewy-body-like aggregation"]
    m6A_manipulation_4["m6A manipulation"] -->|modulates| proteostasis["proteostasis"]
    sess_b7f886d9_da3f_4e0d_a["sess_b7f886d9-da3f-4e0d-a8a8-9c262e268796_task_66f1207e_recon"] -->|causal extracted| processed["processed"]
    style m6A_modification fill:#4fc3f7,stroke:#333,color:#000
    style Parkinson_s_disease fill:#ef5350,stroke:#333,color:#000
    style m6A_modification_1 fill:#4fc3f7,stroke:#333,color:#000
    style alpha_synuclein_transcrip fill:#4fc3f7,stroke:#333,color:#000
    style m6A_modification_2 fill:#4fc3f7,stroke:#333,color:#000
    style alpha_synuclein_aggregati fill:#4fc3f7,stroke:#333,color:#000
    style m6A_writers_erasers_reade fill:#4fc3f7,stroke:#333,color:#000
    style alpha_synuclein_biology fill:#4fc3f7,stroke:#333,color:#000
    style dopaminergic_neuron_pertu fill:#4fc3f7,stroke:#333,color:#000
    style m6A_mediated_alpha_synucl fill:#4fc3f7,stroke:#333,color:#000
    style alpha_synuclein_aggregati_3 fill:#4fc3f7,stroke:#333,color:#000
    style neurodegeneration_in_Subs fill:#4fc3f7,stroke:#333,color:#000
    style cell_state_stratification fill:#4fc3f7,stroke:#333,color:#000
    style causal_subpopulation_effe fill:#4fc3f7,stroke:#333,color:#000
    style m6A_manipulation fill:#4fc3f7,stroke:#333,color:#000
    style broad_toxicity fill:#4fc3f7,stroke:#333,color:#000
    style m6A_RNA_modification fill:#4fc3f7,stroke:#333,color:#000
    style Lewy_body_like_aggregatio fill:#4fc3f7,stroke:#333,color:#000
    style m6A_manipulation_4 fill:#4fc3f7,stroke:#333,color:#000
    style proteostasis fill:#4fc3f7,stroke:#333,color:#000
    style sess_b7f886d9_da3f_4e0d_a fill:#4fc3f7,stroke:#333,color:#000
    style processed fill:#4fc3f7,stroke:#333,color:#000