Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALPHA-SYNUCLEIN AGGREGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALPHA-SYNUCLEIN AGGREGATION |
Knowledge base pages for this entity
graph TD
ALPHA_SYNUCLEIN_AGGREGATION["ALPHA-SYNUCLEIN AGGREGATION"]
ALPHA_SYNUCLEIN_AGGREGATION -->|"causes"| Parkinson_s_Disease["Parkinson's Disease"]
ALPHA_SYNUCLEIN_AGGREGATION -->|"causes"| Neurodegeneration["Neurodegeneration"]
ALPHA_SYNUCLEIN_AGGREGATION -->|"causes"| CNS_Inflammation["CNS Inflammation"]
ALPHA_SYNUCLEIN_AGGREGATION -->|"interacts"| Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
Short_Chain_Fatty_Acids["Short-Chain Fatty Acids"] -->|"modulates"| ALPHA_SYNUCLEIN_AGGREGATION
BMAL1["BMAL1"] -->|"promotes"| ALPHA_SYNUCLEIN_AGGREGATION
Piperine["Piperine"] -->|"inhibits"| ALPHA_SYNUCLEIN_AGGREGATION
ceftriaxone["ceftriaxone"] -->|"inhibits"| ALPHA_SYNUCLEIN_AGGREGATION
Polyamines["Polyamines"] -->|"modulates"| ALPHA_SYNUCLEIN_AGGREGATION
Ceftriaxone["Ceftriaxone"] -->|"inhibits"| ALPHA_SYNUCLEIN_AGGREGATION
SNCA["SNCA"] -->|"involved_in"| ALPHA_SYNUCLEIN_AGGREGATION| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | causes | disease | 0.95 |
| Parkinson's Disease | associated_with | disease | 0.95 |
| Mitochondrial Depolarization | causes | phenotype | 0.93 |
| Dopaminergic Neurons | causes | cell_type | 0.92 |
| ATP Production | downregulates | phenotype | 0.90 |
| Autophagy-Lysosomal Pathway | involved_in | pathway | 0.90 |
| microtubule destabilization | drives | process | 0.90 |
| Parkinson's Disease | contributes_to | disease | 0.90 |
| Parkinson's Disease | causes | disease | 0.90 |
| Mitochondrial Fragmentation | causes | phenotype | 0.89 |
| CNS Inflammation | causes | process | 0.85 |
| dopaminergic neuron loss | contributes_to | phenotype | 0.85 |
| Neurodegeneration | causes | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SNCA | involved_in | gene | 0.95 |
| Short-Chain Fatty Acids | modulates | compound | 0.90 |
| BMAL1 | promotes | gene | 0.90 |
| Piperine | inhibits | compound | 0.90 |
| D-520 | suppresses | drug | 0.90 |
| BMAL1 | inhibits | gene | 0.85 |
| ceftriaxone | inhibits | drug | 0.85 |
| SNCA | regulates | gene | 0.85 |
| Polyamines | modulates | compound | 0.80 |
| Ceftriaxone | inhibits | drug | 0.80 |
| SNCA | involved_in | protein | 0.80 |
| SCFAS | inhibits | compound | 0.80 |
| gut microbiota | promotes | process | 0.80 |
| neuroinflammation | promotes | process | 0.80 |
| Dorsal Motor Nucleus of the Vagus Nerve | associated_with | cell_type | 0.70 |
| Olfactory Bulb | associated_with | cell_type | 0.70 |
| Ferroptosis | modulates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||