tight-junction remodeling is the actionable driver in: Blood-brain barrier permeability changes as early biomarkers for neurodegeneration

flowchart TD
    A["Tight Junction Complex<br/>CLDN5 and OCLN Assembly"]
    B["Paracellular Barrier Integrity<br/>Selective Permeability"]
    C["Inflammatory Mediators<br/>VEGF TNF and IL-1beta"]
    D["ZO-1 Scaffold Dissociation<br/>TJ Protein Phosphorylation"]
    E["Claudin-5 Internalization<br/>Lysosomal Degradation Route"]
    F["BBB Leakage<br/>Albumin and Fibrinogen Entry"]
    G["Neuroinflammation<br/>Peripheral Immune Cell Infiltration"]
    A --> B
    C -.->|"disrupts"| A
    C --> D
    D --> E
    E --> F
    F --> G
    style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style C fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
    style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a
    style G fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a