gene

VCAM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VCAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

174Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

3Debates

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🧬 Gene Info

Gene Symbol	VCAM1
Full Name	Vascular Cell Adhesion Molecule 1
Aliases	CD106
Chromosome	1p21.2
Function	Cell adhesion molecule mediating leukocyte endothelial attachment
Molecular Weight	81.3 kDa
Amino Acids	739
Pathways	Leukocyte extravasation, NF-kB signaling
UniProt ID	P19320
NCBI Gene ID	7412
Ensembl ID	ENSG00000162692
GeneCards	VCAM1
Human Protein Atlas	VCAM1
Associated Diseases	Als, Alzheimer, dementia, Inflammation, Multiple Sclerosis
Interactions	Akt, AKT, AMPK, APOPTOSIS, BAX, BCL-2
KG Connections	174 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VCAM1 — AlphaFold P19320 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VCAM1 - Vascular Cell Adhesion Molecule 1

gene · 1654 words

→

VCAM1 Protein

protein · 1415 words

→

Pathway Diagram

graph TD
    VCAM1["VCAM1"] -.->|"inhibits"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -->|"activates"| Diabetes["Diabetes"]
    style Diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    TNF["TNF"] -->|"associated"| VCAM1["VCAM1"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CXCL10["CXCL10"] -->|"associated"| VCAM1["VCAM1"]
    style CXCL10 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    BAX["BAX"] -.->|"inhibits"| VCAM1["VCAM1"]
    style BAX fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GENES["GENES"] -->|"associated"| VCAM1["VCAM1"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CXCL2["CXCL2"] -->|"associated"| VCAM1["VCAM1"]
    style CXCL2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style VCAM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (121)

Target	Relation	Type	Str
kidney inflammation	mediates	process	0.85
Multiple Sclerosis	implicated_in	disease	0.80
blood-brain barrier permeability changes	associated_with	mechanism	0.70
Atherosclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Dementia	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Als	inhibits	disease	0.65
Cancer	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Diabetes	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
PCSK9	inhibits	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Cholesterol	inhibits	pathway	0.60
CYTOKINES	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
HO-1	activates	gene	0.60
AMPK	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Mtor	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
AKT	regulates	gene	0.60
stem cells	expressed_in	cell_type	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
glioblastoma	regulates	disease	0.60
Macrophage	activates	cell_type	0.60
APOE	regulates	gene	0.60

Incoming (53)

Source	Relation	Type	Str
TNF	associated_with	gene	0.70
BAX	inhibits	gene	0.60
CXCL2	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
ICAM1	inhibits	gene	0.60
ENO1	biomarker_for	gene	0.60
MAP2K1	biomarker_for	gene	0.60
PI3K	regulates	gene	0.60
VEGF	associated_with	gene	0.60
GAPDH	biomarker_for	gene	0.60
ANGPT1	associated_with	gene	0.60
CXCR4	associated_with	gene	0.60
GJA1	associated_with	gene	0.60
BACE1	protects_against	gene	0.60
AKT	regulates	gene	0.60
CXCL1	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
IL-6	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
LDHB	biomarker_for	gene	0.60
CCL2	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CXCL10	associated_with	gene	0.60
DEMENTIA	expressed_in	gene	0.60
GENES	regulates	gene	0.60
CXCL1	activates	gene	0.60
CD44	associated_with	gene	0.60
CD44	regulates	gene	0.60
CD47	regulates	gene	0.60
ERK	activates	gene	0.60
ICAM1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ICAM1	activates	gene	0.60
TNF	activates	gene	0.60
GENES	associated_with	gene	0.60
BCL-2	inhibits	gene	0.60
AKT	activates	gene	0.60
SLC16A1	regulates	gene	0.60
MICROGLIA	inhibits	gene	0.60
NEURON	biomarker_for	gene	0.60
GLUT1	biomarker_for	gene	0.60
ALZHEIMER	protects_against	gene	0.60
PERICYTE	biomarker_for	gene	0.60
MICROGLIA	protects_against	gene	0.60
HMOX1	regulates	gene	0.60
GBM	regulates	gene	0.60
IL1B	expressed_in	gene	0.60
IL6	expressed_in	gene	0.60
TNFA	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.362

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Formal debate: plasma GFAP separates causal from compensatory states in: Blood-b

closed · Rounds: 3 · Score: 0.75 · 2026-04-26

Formal debate: tight-junction remodeling is the actionable driver in: Blood-brai

closed · Rounds: 3 · Score: 0.75 · 2026-04-26

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

closed · Rounds: 4 · Score: 0.78 · 2026-04-26

Related Research

Hypotheses and analyses mentioning VCAM1 in their description or question text

No additional research found