gene

VCAM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VCAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

177Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	VCAM1
Full Name	Vascular Cell Adhesion Molecule 1
Aliases	CD106
Chromosome	1p21.2
Function	Cell adhesion molecule mediating leukocyte endothelial attachment
Molecular Weight	81.3 kDa
Amino Acids	739
Pathways	Leukocyte extravasation, NF-kB signaling
UniProt ID	P19320
NCBI Gene ID	7412
Ensembl ID	ENSG00000162692
GeneCards	VCAM1
Human Protein Atlas	VCAM1
Official Name	Vascular Cell Adhesion Molecule 1
NCBI Reference	NM_001078
Associated Diseases	Als, Alzheimer, Inflammation, Multiple Sclerosis, dementia
Interactions	LDLR, TNF, NOX4, SOD2, NRF2, CXCL1
KG Connections	177 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VCAM1 — AlphaFold P19320 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VCAM1["VCAM1"] -.->|"inhibits"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -.->|"inhibits"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    VCAM1["VCAM1"] -->|"activates"| Diabetes["Diabetes"]
    style Diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    TNF["TNF"] -->|"associated"| VCAM1["VCAM1"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CXCL10["CXCL10"] -->|"associated"| VCAM1["VCAM1"]
    style CXCL10 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    BAX["BAX"] -.->|"inhibits"| VCAM1["VCAM1"]
    style BAX fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GENES["GENES"] -->|"associated"| VCAM1["VCAM1"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CXCL2["CXCL2"] -->|"associated"| VCAM1["VCAM1"]
    style CXCL2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style VCAM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (123)

Target	Relation	Type	Str
kidney inflammation	mediates	process	0.85
Multiple Sclerosis	implicated_in	disease	0.80
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Diabetes	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Als	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Tumor	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
ICAM1	associated_with	gene	0.60
LDLR	inhibits	gene	0.60
TNF	inhibits	gene	0.60
LMNA	biomarker_for	gene	0.60
GAPDH	biomarker_for	gene	0.60
NOX4	activates	gene	0.60
SOD2	activates	gene	0.60
NRF2	activates	gene	0.60
AKT	regulates	gene	0.60
APOE	regulates	gene	0.60
MTOR	regulates	gene	0.60
MAP2K1	biomarker_for	gene	0.60
CXCL1	activates	gene	0.60
CD44	associated_with	gene	0.60
GJA1	associated_with	gene	0.60
CD47	regulates	gene	0.60
CD44	regulates	gene	0.60
SLC16A1	regulates	gene	0.60
MTOR	activates	gene	0.60
ANGPT1	associated_with	gene	0.60
CXCR4	associated_with	gene	0.60
HMOX1	regulates	gene	0.60
IBA1	protects_against	gene	0.60

Incoming (54)

Source	Relation	Type	Str
TNF	associated_with	gene	0.70
CXCL10	associated_with	gene	0.60
BAX	inhibits	gene	0.60
CXCL2	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
ICAM1	inhibits	gene	0.60
ENO1	biomarker_for	gene	0.60
MAP2K1	biomarker_for	gene	0.60
ICAM1	expressed_in	gene	0.60
PI3K	regulates	gene	0.60
VEGF	associated_with	gene	0.60
GAPDH	biomarker_for	gene	0.60
ANGPT1	associated_with	gene	0.60
CXCR4	associated_with	gene	0.60
HMOX1	regulates	gene	0.60
GBM	regulates	gene	0.60
AKT	activates	gene	0.60
GJA1	associated_with	gene	0.60
CXCL1	activates	gene	0.60
CD44	associated_with	gene	0.60
CD44	regulates	gene	0.60
CD47	regulates	gene	0.60
BACE1	protects_against	gene	0.60
SLC16A1	regulates	gene	0.60
AKT	regulates	gene	0.60
CXCL1	regulates	gene	0.60
IL1B	expressed_in	gene	0.60
IL6	expressed_in	gene	0.60
TNFA	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ICAM1	activates	gene	0.60
TNF	activates	gene	0.60
GENES	associated_with	gene	0.60
BCL-2	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
ERK	activates	gene	0.60
NF-ΚB	regulates	gene	0.60
IL-6	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	biomarker_for	gene	0.60
LDHB	biomarker_for	gene	0.60
CCL2	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
GENES	regulates	gene	0.60
NEURON	biomarker_for	gene	0.60
GLUT1	biomarker_for	gene	0.60
ALZHEIMER	protects_against	gene	0.60
PERICYTE	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VCAM1

Understanding Entity Pages

Wiki Pages (12)

VCAM1 - Vascular Cell Adhesion Molecule 1

Disease-Associated Oligodendrocytes

PECAM1 - Platelet Endothelial Cell Adhesion Molecule 1

ICAM1 - Intercellular Adhesion Molecule 1

PECAM1 Protein

VCAM1 Protein

ICAM1 Protein

IL1A — Interleukin 1 Alpha

MAP2K1 Gene

JAM2 - Junctional Adhesion Molecule 2