GPX4 reserve failure gates selective ALS motor-neuron ferroptosis

flowchart TD
A["ALS proteostasis stress"] --> B["GPX4 reserve depletion"]
A --> C["Glutathione depletion"]
B --> D["Oxidized phospholipid accumulation"]
C --> D
D --> E{"Ferroptotic threshold crossed?"}
E -->|" Yes "| F["Ferroptosis activation"]
F --> G["Motor neuron death"]
E -->|" No "| H["Motor neuron survival"]
B --> I["GPX4 activity restoration"]
C --> J["Glutathione supplementation"]
I --> K["Neuroprotection"]
J --> K
K -->|" Rescues "| G

style A fill:#ffd54f,color:#0d0d1a
style B fill:#4fc3f7,color:#0d0d1a
style C fill:#4fc3f7,color:#0d0d1a
style D fill:#4fc3f7,color:#0d0d1a
style E fill:#ef5350,color:#0d0d1a
style F fill:#ef5350,color:#0d0d1a
style G fill:#ef5350,color:#0d0d1a
style I fill:#81c784,color:#0d0d1a
style J fill:#81c784,color:#0d0d1a
style K fill:#81c784,color:#0d0d1a