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Relevance of mitochondrial genetics and metabolism in cancer development.
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ID: paper-23378588
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Relevance of mitochondrial genetics and metabolism in cancer development.
["Gasparre G", "Porcelli A", "Lenaz G", "Romeo G"]
Abstract
Cancer cells are characterized in general by a decrease of mitochondrial respiration and oxidative phosphorylation, together with a strong enhancement of glycolysis, the so-called Warburg effect. The decrease of mitochondrial activity in cancer cells may have multiple reasons, related either to the input of reducing equivalents to the electron transfer chain or to direct alterations of the mitochondrial respiratory complexes. In some cases, the depression of respiratory activity is clearly the c...
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