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The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peripheral Inflammatory Networks.
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📄 Paper Details
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peripheral Inflammatory Networks.
Gopalakrishna PK, Che Mohd Nassir CMN, Anandan S, Hussan F, Dandala KCR, Sura S, Jagadeesan S, Mohd Moklas MA, Vishnumukkala T, Hein ZM
Abstract
UNLABELLED: Alzheimer’s disease (AD) is increasingly recognized as a disorder of dysregulated neuroimmune connectivity rather than isolated proteinopathy. The immuno-glial connectome, the dynamic interplay between microglia, astrocytes, and peripheral immune systems, constitutes a central driver of disease initiation and progression. Emerging single-cell and spatial transcriptomic studies reveal heterogeneous glial subpopulations with context-dependent transcriptional programs governed by TREM2–...
▸Metadata
| doi | 10.1007/s10571-026-01671-4 |
| pmid | 41569436 |
| year | 2026 |
| pmc_id | None |
| _origin | {'url': 'https://pubmed.ncbi.nlm.nih.gov/41569436/', 'type': 'external', 'tracked_at': '2026-04-23T20:17:18.162458'} |
| authors | ['Gopalakrishna PK', 'Che Mohd Nassir CMN', 'Anandan S', 'Hussan F', 'Dandala KCR', 'Sura S', 'Jagadeesan S', 'Mohd Moklas MA', 'Vishnumukkala T', 'Hein ZM'] |
| journal | Cellular and molecular neurobiology |
| _schema_version | 1 |
| quality_scoring | {'quality_status_review': {'status': 'pass', 'signals': ['has_provenance_chain', 'has_metadata'], 'task_id': '3854fa92-f632-4cba-be41-396420da7151', 'rationale': 'quality_status assigned by automated |
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