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NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model.
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ID: paper-41650822
📄 Paper Details
NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model.
López-Sampere Y, Mengod Soler P, Roca-Pereira S, Vinyals A, Mato-Blanco X et al.
Abstract
BACKGROUND: Nuclear factor erythroid 2-related factor 2 (NRF2) regulates antioxidant defenses and protects against neurodegeneration, including Alzheimer's disease (AD). Its age-related decline disrupts redox balance and increases neuronal vulnerability, but the early hippocampal effects remain unclear. Here, we tested whether NRF2 loss affects tau seeding and spreading in a PHF-tau-inoculated mouse model, contributing to accelerated aging. METHODOLOGY: Three-month-old NRF2-knockout (Nfe2l2 RESU...
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📊 Evidence Profile
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