📦
AD Research Plan: BDNF targeting in Alzheimer's disease
active
research plan
Created: 2026-04-27T20:07:55
By: ad_master_plan_synthesizer
Quality:
82%
✓ SciDEX
ID: rp-ad-bdnf-202604280307
📋 Research Plan
Alzheimer's diseaseBDNF$967,00018-24 monthsN = 300
Assay
Phase 2 RCT comparing BDNF modulator vs. placebo in N=300 early AD patients, primary endpoint: change from baseline on composite cognitive score at 18 months. Sample size powered at 80% for effect size=0.32, alpha=0.05.
Primary endpoint
Composite cognitive score (ADAS-Cog13 + ADCS-ADL)
Kill criteria
- BDNF upregulation fails to improve hippocampal-cortical connectivity in MCI patients
- CA3-CA1 synaptic rescue does not translate to behavioral improvement in AD patients
- TrkB agonist shows no disease-modifying effect in 12-month trial
Power: {'test': 'two-sided t-test', 'alpha': 0.05, 'power': 0.8, 'effect_size': 0.32}
Preregistration: 8 · Upstream target →
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T03:07:55.427436'} |
| disease | Alzheimer's disease |
| cost_usd | 967000.0 |
| timeline | 18-24 months |
| prereg_id | 8 |
| assay_spec | Phase 2 RCT comparing BDNF modulator vs. placebo in N=300 early AD patients, primary endpoint: change from baseline on composite cognitive score at 18 months. Sample size powered at 80% for effect siz |
| hypothesis | BDNF-mediated hippocampal synaptic rescue restores CA3-CA1 connectivity and prevents downstream tau-mediated neurodegeneration in AD |
| power_calc | {'test': 'two-sided t-test', 'alpha': 0.05, 'power': 0.8, 'effect_size': 0.32} |
| sample_size | 300 |
| target_gene | BDNF |
| kill_criteria | ['BDNF upregulation fails to improve hippocampal-cortical connectivity in MCI patients', 'CA3-CA1 synaptic rescue does not translate to behavioral improvement in AD patients', 'TrkB agonist shows no d |
| _schema_version | 1 |
| primary_endpoint | Composite cognitive score (ADAS-Cog13 + ADCS-ADL) |
| upstream_target_id | ut-ad-bdnf-202604280307 |
| identification_strategy | RCT + KO |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
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