Conference: AAIC 2026 | Dates: July 12-15, 2026 | Location: Excel London, UK
Overview
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Metabolic dysfunction is increasingly recognized as a central feature of Alzheimer's disease, with brain insulin resistance, mitochondrial dysfunction, and impaired glucose metabolism contributing to cognitive decline. AAIC 2026 features comprehensive coverage of metabolic interventions, from novel therapeutics to lifestyle modifications["@cunnane2024"].
Key Topics
... Conference: AAIC 2026 | Dates: July 12-15, 2026 | Location: Excel London, UK
Overview
Mermaid diagram (expand to render)
Metabolic dysfunction is increasingly recognized as a central feature of Alzheimer's disease, with brain insulin resistance, mitochondrial dysfunction, and impaired glucose metabolism contributing to cognitive decline. AAIC 2026 features comprehensive coverage of metabolic interventions, from novel therapeutics to lifestyle modifications["@cunnane2024"].
Key Topics
Reduced cerebral glucose uptake : Early feature of ADPET FDG imaging markers : Diagnostic and prognostic valueRelationship to amyloid and tau : Independent pathological contributionsMitochondrial Dysfunction
Complex I impairment : Electron transport chain defectsATP production deficits : Energy crisis in neuronsReactive oxygen species : Oxidative stress from mitochondriaInsulin Signaling in the Brain
Brain Insulin Resistance
IRS-1 signaling defects : Downstream pathway disruptionPI3K/Akt impairment : Synaptic plasticity effectsFOXO transcription factors : Gene expression alterationsInsulinotropic Therapies
Intranasal insulin : Direct CNS delivery approachesInsulin sensitizers : PPARγ agonists and related compoundsGLP-1 receptor agonists : Incretin effects in brain
Ketone Body Utilization
BHB (β-hydroxybutyrate) : Alternative brain fuelKetogenic diets : Dietary interventionsExogenous ketones : Supplementation strategiesGlucose-to-ketone switch : Enhancing brain resilienceMCT transporters : Monocarboxylate transporters in brainAge-related decline : How metabolic flexibility changes
Brain Cholesterol Dysregulation
Cholesterol synthesis : Local production in neuronsAPOE and lipid transport : Role of APOE4Membrane lipid composition : Effects on synaptic functionLipid-Targeting Therapies
Statins : Cholesterol-lowering in AD trialsLiver X receptor agonists : Nuclear receptor targetingFatty acid oxidation modulators : Metabolic pathway effectsTherapeutic Approaches
Antidiabetic Drugs in AD
Metformin : AMPK activation and beyondGLP-1 analogues : Liraglutide, semaglutide in trialsSGLT2 inhibitors : Renal glucose reabsorption inhibitionMitochondrial-Targeted Compounds
Mitochondrial antioxidants : MitoQ, CoQ10Complex I optimizers : Electron transfer enhancersMitophagy inducers : Enhancing mitochondrial quality controlDietary and Lifestyle Interventions
Ketogenic Interventions
Classic ketogenic diet : High-fat, low-carbohydrateMCT oil supplementation : Medium-chain triglyceridesTime-restricted eating : Fasting effects on brainCaloric Restriction
Intermittent fasting : 16:8 and similar patternsCaloric restriction mimetics : Pharmacologic approachesAutophagy induction : Cellular cleanup mechanisms
NAD+ Boosters
NMN (nicotinamide mononucleotide) : NAD+ precursorNR (nicotinamide riboside) : Alternative precursorPARP inhibitors : Preserving NAD+ poolsAMPK Activators
AICAR : AMPK agonist in developmentMetformin : Established AMPK activatorHerbal compounds : Natural AMPK activatorsNotable Sessions
Symposia
"Brain Insulin Resistance: From Mechanism to Therapy"
"Ketone Bodies as Therapeutic Agents in Alzheimer's"
"Mitochondrial Dysfunction: The Missing Link in AD"
Workshops
"Metabolic Biomarkers in Clinical Trials"
"FDG-PET: Beyond Diagnosis"
"Dietary Interventions for Cognitive Health"
Related NeuroWiki Content
[Mitochondrial Dysfunction in AD](/mechanisms/mitochondrial-dysfunction)
[Brain Insulin Signaling Pathway](/entities/brain-insulin-signaling)
[Metabolic Stress in Neurodegeneration](/mechanisms/metabolic-stress)
Autophagy-Lysosome Pathway
Oxidative Stress Response
See Also
[AAIC 2026 Conference](/events/aaic-2026)
[AAIC 2026: Therapeutic Approaches](/events/aaic-2026/therapeutic-approaches)
[AAIC 2026: Neuroinflammation](/events/aaic-2026/neuroinflammation)
[Alzheimer's Disease](/diseases/alzheimers-disease)
References
[Cunnane SC, et al., Brain fuel metabolism, aging, and Alzheimer's disease. Nat Rev Neurol. 2024 (2024)](https://doi.org/10.1038/s41582-024-00856-0)
[Craft S, et al., Insulin resistance and Alzheimer's disease: Bioenergetic mechanisms. Nat Rev Neurosci. 2023 (2023)](https://doi.org/10.1038/s41583-023-00678-4)
[Gibson GE, et al., Mitochondrial dysfunction in Alzheimer's disease. Ann Neurol. 2024 (2024)](https://doi.org/10.1002/ana.26947) Show full description