Metabolic Reprogramming via Microglial Glycolysis Inhibition

## **Molecular Mechanism and Rationale** The therapeutic strategy of metabolic reprogramming through microglial glycolysis inhibition represents a novel approach to neurodegeneration that exploits the fundamental metabolic differences between inflammatory M1 and anti-inflammatory M2 microglial phenotypes. At the molecular level, this intervention targets hexokinase 2 (HK2), the rate-limiting enzyme in glycolysis that catalyzes the phosphorylation of glucose to glucose-6-phosphate. HK2 is partic...