Adenosine-Astrocyte Metabolic Reset

**Molecular Mechanism and Rationale** The molecular underpinnings of adenosine A2A receptor (ADORA2A) modulation in astrocytic metabolism represent a sophisticated interplay of cellular signaling, metabolic regulation, and neuroenergetic optimization. At the core of this hypothesis lies a complex molecular mechanism that integrates multiple cellular processes through a nuanced receptor-mediated signaling cascade. ADORA2A activation triggers a multi-step molecular response that begins with G-pr...