HSPA10 — Heat Shock Protein Family A Member 10

HSPA10 — Heat Shock Protein Family A Member 10

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">HSPA10 — Heat Shock Protein Family A (Hsp70) Member 10</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>HSPA10</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Heat Shock Protein Family A (Hsp70) Member 10</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>12q13.12</td>
</tr>
<tr>
<td class="label">NCBI Gene</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/3336" target="_blank">3336</a></td>
</tr>
<tr>
<td class="label">OMIM</td>
<td><a href="https://omim.org/entry/610175" target="_blank">610175</a></td>
</tr>
<tr>
<td class="label">Ensembl</td>
<td><a href="https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113013" target="_blank">ENSG00000113013</a></td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/P54652" target="_blank">P54652</a></td>
</tr>
<tr>
<td class="label">Diseases</td>
<td>[Lung Cancer](/diseases/lung-cancer), [Breast Cancer](/diseases/breast-cancer), [Autoimmune Disorders](/diseases/autoimmune), [Chronic Inflammation](/diseases/chronic-inflammation)</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Ubiquitous, highest in lymphoid tissues, testes, placenta</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

HSPA10 — Heat Shock Protein Family A Member 10

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">HSPA10 — Heat Shock Protein Family A (Hsp70) Member 10</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>HSPA10</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Heat Shock Protein Family A (Hsp70) Member 10</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>12q13.12</td>
</tr>
<tr>
<td class="label">NCBI Gene</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/3336" target="_blank">3336</a></td>
</tr>
<tr>
<td class="label">OMIM</td>
<td><a href="https://omim.org/entry/610175" target="_blank">610175</a></td>
</tr>
<tr>
<td class="label">Ensembl</td>
<td><a href="https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113013" target="_blank">ENSG00000113013</a></td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/P54652" target="_blank">P54652</a></td>
</tr>
<tr>
<td class="label">Diseases</td>
<td>[Lung Cancer](/diseases/lung-cancer), [Breast Cancer](/diseases/breast-cancer), [Autoimmune Disorders](/diseases/autoimmune), [Chronic Inflammation](/diseases/chronic-inflammation)</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Ubiquitous, highest in lymphoid tissues, testes, placenta</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

HSPA10 — Heat Shock Protein Family A (Hsp70) Member 10

Introduction

HSPA10, also known as Hsp70L1 (Heat Shock Protein 70-Like 1) or Hsp70-5, is a member of the Hsp70 family of molecular chaperones. While initially characterized as a testis-specific Hsp70 protein, HSPA10 has emerged as a multifunctional protein involved in immune regulation, protein folding, and cellular stress responses.

Overview

HSPA10 encodes a 641-amino acid protein belonging to the Hsp70 family. Unlike canonical Hsp70s, HSPA10 lacks the C-terminal substrate-binding domain variability and is primarily localized to the cytosol and nucleus. HSPA10 is constitutively expressed at low levels and is upregulated in response to various cellular stresses.

Function

Molecular Chaperone Activity

HSPA10 functions as a molecular chaperone, assisting in protein folding, refolding, and assembly of protein complexes. Like other Hsp70 family members, HSPA10 utilizes ATP-dependent substrate binding and release cycles to facilitate protein homeostasis.

Immune Regulation

HSPA10 plays significant roles in immune function:

• T-cell activation: HSPA10 is overexpressed in activated T cells and functions as a co-stimulatory molecule
• Antigen presentation: HSPA10 associates with components of the antigen processing machinery
• Cytokine regulation: HSPA10 modulates inflammatory cytokine production

Cancer Biology

HSPA10 is frequently overexpressed in various cancers and is associated with:

• Tumor cell proliferation and survival
• Resistance to chemotherapy
• Immune evasion
• Poor patient prognosis

Disease Associations

Cancer

HSPA10 overexpression is observed in lung cancer, breast cancer, colorectal cancer, and other malignancies. HSPA10 promotes tumor progression through:

• Enhanced cell survival under stress
• Inhibition of [apoptosis](/entities/apoptosis)
• Promotion of angiogenesis

Autoimmune Disorders

HSPA10 may play complex roles in autoimmunity:

• Molecular mimicry between Hsp60 and Hsp70 family members
• Modulation of regulatory T cell function
• Altered expression in systemic lupus erythematosus (SLE) and rheumatoid arthritis

Chronic Inflammation

HSPA10 expression is modulated in chronic inflammatory conditions, and the protein may serve both pro-inflammatory and anti-inflammatory roles depending on context.

Expression

HSPA10 exhibits widespread expression with highest levels in:

• Testis
• Lymphoid tissues (spleen, thymus, lymph nodes)
• Placenta
• Bone marrow

Therapeutic Implications

HSPA10 represents a therapeutic target for:

• Cancer therapy through targeting Hsp70-mediated cell survival
• Autoimmune modulation
• Development of HSPA10-specific inhibitors
• Immunotherapy targeting HSPA10-expressing tumors

See Also

• [HSP70 Family](/mechanisms/hsp70-family)
• [Heat Shock Proteins](/heat-shock-proteins)
• [Protein Folding](/mechanisms/protein-folding)
• [Molecular Chaperones](/mechanisms/molecular-chaperones)
• [Immunology](/mechanisms/immune-system)

External Links

• [NCBI Gene: HSPA10](https://www.ncbi.nlm.nih.gov/gene/3336)
• [UniProt: HSPA10](https://www.uniprot.org/uniprot/P54652)
• [Ensembl: HSPA10](https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113013)

References