RPA2 Gene
Introduction
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">RPA2 Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>RPA2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Replication Protein A2</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>1p35.3</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>[9138](https://www.ncbi.nlm.nih.gov/gene/9138)</td>
</tr>
<tr>
<td class="label">OMIM</td>
<td>[179836](https://www.omim.org/entry/179836)</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000117748</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>[P33240](https://www.uniprot.org/uniprot/P33240)</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Ataxia-telangiectasia](/diseases/ataxia-telangiectasia)</td>
</tr>
</table>
Rpa2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@dna2020]
title: RPA2 [@dna2021]
--- [@rpa2021]
:: infobox .infobox-gene [^5]
::
Overview
...RPA2 Gene
Introduction
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">RPA2 Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>RPA2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Replication Protein A2</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>1p35.3</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>[9138](https://www.ncbi.nlm.nih.gov/gene/9138)</td>
</tr>
<tr>
<td class="label">OMIM</td>
<td>[179836](https://www.omim.org/entry/179836)</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000117748</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>[P33240](https://www.uniprot.org/uniprot/P33240)</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Ataxia-telangiectasia](/diseases/ataxia-telangiectasia)</td>
</tr>
</table>
Rpa2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@dna2020]
title: RPA2 [@dna2021]
--- [@rpa2021]
:: infobox .infobox-gene [^5]
::
Overview
RPA2 (Replication Protein A2) encodes the 32 kDa subunit of the heterotrimeric Replication Protein A complex, which is essential for DNA replication, repair, and recombination. As the regulatory subunit of RPA, RPA2 plays critical roles in DNA damage response signaling through phosphorylation by ATM and ATR kinases. This gene is highly conserved across eukaryotes and is expressed in all proliferating cells as well as post-mitotic [neurons](/entities/neurons). Mutations or dysregulation of RPA2 have been implicated in neurodegenerative diseases, highlighting the importance of DNA repair mechanisms in neuronal survival.
Function
RPA2 (Replication Protein A2) is the middle subunit of the RPA heterotrimeric complex (RPA1, RPA2, RPA3). RPA2 is the regulatory subunit that undergoes extensive phosphorylation in response to DNA damage. ATM and ATR kinases phosphorylate RPA2, modulating its function in DNA repair and checkpoint activation [1](https://doi.org/10.1016/j.tibs.2020.03.013).
In neurons, RPA2 phosphorylation is an important signaling event in response to DNA damage. The ATM/ATR-RPA2 pathway helps coordinate DNA repair and cell survival decisions in post-mitotic neurons.
Disease Associations
Alzheimer's Disease
RPA2 phosphorylation is altered in AD brains, reflecting dysregulated DNA damage responses. The accumulation of neuronal DNA damage in AD may overwhelm the RPA-mediated repair pathway [2](https://doi.org/10.1016/j.neurobiolaging.2020.08.014).
Parkinson's Disease
RPA2-mediated DNA repair is important for maintaining dopaminergic neuron genomic stability. Defects in this pathway may contribute to the selective vulnerability of these neurons in PD [3](https://doi.org/10.1002/mds.28456).
Ataxia-Telangiectasia
ATM-mediated phosphorylation of RPA2 is impaired in AT patients, contributing to the characteristic sensitivity to ionizing radiation and increased cancer risk.
Expression
RPA2 is expressed in all brain regions, with highest expression in the [hippocampus](/brain-regions/hippocampus) and cerebral [cortex](/brain-regions/cortex). Like RPA1, neuronal expression is maintained throughout life.
Background
The study of Rpa2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Pathway & Interaction Diagram
Interactive diagram showing RPA2's key relationships in the SciDEX knowledge graph (8 connections shown).
Mermaid diagram (expand to render)
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
- [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
- [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
References
[@rpa2021]: [RPA phosphorylation [^5]: [Neuronal DNA damage response in neurodegeneration (2021)](https://[^6]: [RPA complex in genome stability (2018)](https://doi.org/10.1016/j.tcb.2018.06.002)
[@atrmediated2017]: [ATR-mediated checkpoint signaling (2017)](https://doi.org/10.1146/annurev-biochem-060614-034335)
[@atm2019]: [ATM and DNA repair in the nervous system (2019)](https://doi.org/10.1016/j.neurobiolaging.2019.06.012)
Cross-Links
- [RPA2 Protein](/proteins/rpa2-protein)
- [RPA1 Gene](/genes/rpa1)
- [ATM Gene](/genes/atm)
- [ATR Gene](/genes/atr)
- [DNA Repair Pathways](/mechanisms/dopaminergic-neuron-vulnerability)
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Parkinson's Disease](/diseases/parkinsons-disease)
See Also
- [RPA1 Gene](/genes/rpa1)
- [RPA3 Gene](/genes/rpa3)
- [RPA2 Protein](/proteins/rpa2-protein)
- [DNA Repair Pathways](/mechanisms/dopaminergic-neuron-vulnerability)
- [DNA Damage Response](/mechanisms/dna-damage-response)
- [Ataxia](/mechanisms/dopaminergic-neuron-vulnerability)