Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RPA2 |
| Full Name | Replication Protein A2 |
| Chromosome | 1p35.3 |
| Function | RPA2 (Replication Protein A2) is the middle subunit of the RPA heterotrimeric complex (RPA1, RPA2, RPA3). |
| Primary Expression | all proliferating cells as well as post-mitotic neurons |
| Molecular Weight | 32 kDa |
| Amino Acids | 270 aa |
| Pathways | Dna Damage Response |
| UniProt ID | P33240 |
| NCBI Gene ID | 9138 |
| Ensembl ID | ENSG00000117748 |
| OMIM | 179836 |
| GeneCards | RPA2 |
| Human Protein Atlas | RPA2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
RPA2(["RPA2"])
Ms["Ms"]
NAD(["NAD"])
SIRT1(["SIRT1"])
DNA(["DNA"])
Dna_Damage_Response["Dna Damage Response"]
AND(["AND"])
neurodegeneration["neurodegeneration"]
RPA2 -->|"regulates"| Ms
RPA2 -->|"regulates"| NAD
RPA2 -->|"regulates"| SIRT1
RPA2 -->|"regulates"| DNA
RPA2 -->|"regulates"| Dna_Damage_Response
SIRT1 -->|"regulates"| RPA2
AND -->|"regulates"| RPA2
RPA2 -->|"implicated in"| neurodegeneration
style RPA2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | regulates | disease | 0.65 |
| SIRT1 | regulates | gene | 0.60 |
| NAD | regulates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| Dna Damage Response | regulates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||