Axonal RNA Transport Reconstitution

**Molecular Mechanism and Rationale** The axonal RNA transport reconstitution hypothesis centers on the critical role of heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) in facilitating kinesin-mediated transport of RNA granules along microtubules in neuronal axons. HNRNPA2B1 functions as a key RNA-binding protein that recognizes specific trafficking signals, particularly the A2 response element (A2RE) sequences found in mRNAs destined for axonal and synaptic localization. Under physio...