GluK2 Protein

GluK2 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">GluK2 Protein</th>
</tr>
<tr>
<td class="label">Drug</td>
<td>Type</td>
</tr>
<tr>
<td class="label">LY466365</td>
<td>Antagonist</td>
</tr>
<tr>
<td class="label">UBP310</td>
<td>Antagonist</td>
</tr>
<tr>
<td class="label">ATPA</td>
<td>Agonist</td>
</tr>
</table>

Gluk2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

:: infobox .infobox-protein [@mulle2021] Protein Name: Glutamate receptor ionotropic kainate 2 [@petzold2019] Gene: [GRIK2](/genes/grik2) [@vincent2018] UniProt ID: [Q13002](https://www.uniprot.org/uniprot/Q13002) [@jane2020] PDB ID: [5KBS](https://www.ebi.ac.uk/pdbe/entry/pdb/5KBS), [7R0F](https://www.ebi.ac.uk/pdbe/entry/pdb/7R0F) [@contractor2019] Molecular Weight: ~100 kDa [@frerking2018] Subcellular Localization: Plasma membrane, postsynaptic density, presynaptic terminals Protein Family: Ionotropic glutamate receptor (kainate receptor)
::

Overview

GLUK2 PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of GLUK2 PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.

Structure

GluK2 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">GluK2 Protein</th>
</tr>
<tr>
<td class="label">Drug</td>
<td>Type</td>
</tr>
<tr>
<td class="label">LY466365</td>
<td>Antagonist</td>
</tr>
<tr>
<td class="label">UBP310</td>
<td>Antagonist</td>
</tr>
<tr>
<td class="label">ATPA</td>
<td>Agonist</td>
</tr>
</table>

Gluk2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

:: infobox .infobox-protein [@mulle2021] Protein Name: Glutamate receptor ionotropic kainate 2 [@petzold2019] Gene: [GRIK2](/genes/grik2) [@vincent2018] UniProt ID: [Q13002](https://www.uniprot.org/uniprot/Q13002) [@jane2020] PDB ID: [5KBS](https://www.ebi.ac.uk/pdbe/entry/pdb/5KBS), [7R0F](https://www.ebi.ac.uk/pdbe/entry/pdb/7R0F) [@contractor2019] Molecular Weight: ~100 kDa [@frerking2018] Subcellular Localization: Plasma membrane, postsynaptic density, presynaptic terminals Protein Family: Ionotropic glutamate receptor (kainate receptor)
::

Overview

GLUK2 PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of GLUK2 PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.

Structure

GluK2 (formerly GluR6) is a kainate receptor subunit with the classic iGluR architecture:

• Ligand-binding domain (LBD): Two lobes (S1 and S2) that bind glutamate
• Transmembrane domain (TMD): Four helices (M1-M4) forming the ion channel pore
• N-terminal domain (ATD): Large extracellular domain involved in assembly and modulation

Normal Function

Kainate receptors, including GluK2-containing receptors, mediate excitatory neurotransmission:

• Fast synaptic transmission: Mediate EPSCs at some synapses
• Presynaptic modulation: Regulate neurotransmitter release via presynaptic receptors
• Neuronal development: Affect migration, axon guidance, and synapse formation
• Pain transmission: Dorsal horn kainate receptors mediate nociception
• Circadian rhythm: Involved in retinal signaling

Role in Disease

Huntington's Disease

• Downregulation of GluK2 in the striatum
• Contributes to altered corticostriatal connectivity

Alzheimer's Disease

• Genetic variants associated with risk
• Dysregulated kainate signaling affects excitotoxicity

Autism Spectrum Disorder

• Missense variants impair receptor function
• Contributes to altered synaptic development

ALS

• Rare variants increase susceptibility
• Affects excitotoxicity pathways

Therapeutic Targeting

Kainate receptor drugs are actively being developed:

Key Publications

See Also

• [GRIK2 Gene](/grik2-gene)
• [Huntington's Disease](/diseases/huntington-disease)
• [Glutamate Excitotoxicity](/mechanisms/glutamate-excitotoxicity)
• [Kainate Receptor](/proteins/kainate-receptor)
• [Synaptic Transmission](/mechanisms/synaptic-transmission)

Background

The study of Gluk2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

References