The mTORC1-TFEB axis controls autophagy capacity. In aging neurons, chronic mTORC1 activation keeps TFEB cytoplasmic, impairing lysosomal biogenesis and autophagic clearance. Strategies to displace mTORC1 from the lysosomal surface (Ragulator disruption, AMPK activation) could restore TFEB nuclear translocation. This challenge asks whether this intervention is sufficient to clear pathological aggregates. Falsifiable prediction: Ragulator inhibition in iPSC-derived neurons from LRRK2-G2019S patients should increase LC3-II flux by ≥3-fold and reduce SNCA aggregate area by ≥40% within 72h.