TFEB

TFEB Protein

Score: 0.480 Price: $0.41 Medium Druggability Status: active

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 TFEB — PDB 5HQB Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Medium

Score: 0.50

Clinical Stage

Phase II

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Therapeutic Areas:

neurodegeneration

Mechanism: Prioritized from 1 SciDEX hypotheses, including: The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction

Known Drugs:

No known drugs targeting this protein

Structural Data:

🧬 3D Protein Structure

🧬 TFEB — PDB 5HQB Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Linked Hypotheses (4)

Cell-Type Specific TFEB Modulation0.482

The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction0.398

TFEB-PGC1α Mitochondrial-Lysosomal Decoupling0.398

Temporal TFEB Modulation Therapy0.366

Linked Experiments (6)

Trehalose-induced lysosomal membrane permeabilization and TFEB activation0.900

Trehalose-induced lysosomal changes and TFEB activation0.900

Transcriptome sequencing of cardiac fibroblasts in TFEB overexpressing mice0.900

TFEB silencing and misfolded protein degradation0.880

Functional validation of trehalose effects on misfolded protein clearance0.850

Trehalose analog testing for autophagy induction0.820

Scoring Dimensions

Knowledge Graph (20)

interacts with (19)

TFEB → NBR1

TFEB → MTOR

TFEB → AMBRA1

TFEB → ATF6

TFEB → HSPA5

...and 14 more

regulates (1)

TFEB → PPARGC1A

Debate History (0)

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