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TFEB

TFEB Protein

Score: 0.337 Price: $0.34 Undruggable Druggability Status: active Wiki: TFEB
HYPOTHESES
1
PAPERS
12
KG EDGES
3
DEBATES
1

3D Protein Structure

🧬 TFEB — PDB 5HQB Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability
Undruggable
Score: 0.23
Clinical Stage
Preclinical
Target Class
Protein
Safety
0.50
Druggability Analysis
Drug Development0.00
Structural Tractability0.30
Target Class0.50
Safety Profile0.50
Key Metrics
PDB Structures:
0
Known Drugs:
0
Approved:
0
In Clinical Trials:
0
Mechanism: Prioritized from 1 SciDEX hypotheses, including: The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Known Drugs:
No known drugs targeting this protein
Structural Data:
PDB —AlphaFold ✓Cryo-EM —
UniProt: O14964

🧬 3D Protein Structure

🧬 TFEB — PDB 5HQB Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

Open full viewer

AlphaFold predicted structure available for O14964

View AlphaFold Structure

Linked Hypotheses (10)

Cell-Type-Specific TFEB Modulation Combined with Trehalose for Targeted Alzheimer's Disease Interven0.000
GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9 Dopaminergic Neurons that is Defective D0.750
Cell-Type Specific TFEB Modulation0.677
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction0.652
Radiation drives pericyte senescence through lysosome acidification failure and stalled late-stage a0.652
SNCA Oligomers Sequester TFEB Phosphatases to Create a Phospho-TFEB Tipping Point that Triggers Irre0.650
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling0.622
Temporal TFEB Modulation Therapy0.609
TFEB Activation Clears Tau-Loaded Endolysosomal Compartments, Preventing Release for Transcellular S0.560
TFEB Activation to Restore Lysosomal Biogenesis in Alzheimer's Disease Neuronal Networks0.523

Linked Experiments (6)

Trehalose-induced lysosomal membrane permeabilization and TFEB activation0.900
Trehalose-induced lysosomal changes and TFEB activation0.900
Transcriptome sequencing of cardiac fibroblasts in TFEB overexpressing mice0.900
TFEB silencing and misfolded protein degradation0.880
Functional validation of trehalose effects on misfolded protein clearance0.850
Trehalose analog testing for autophagy induction0.820

Scoring Dimensions

Portfolio 0.00 (25%) Druggability 0.23 (20%) Evidence 0.84 (20%) Safety 0.50 (15%) Competitive 0.50 (10%) Connectivity 0.00 (10%) 0.337 composite

Knowledge Graph (20)

activates (8)

trehalose→TFEBhederagenin→TFEBTFEB→Autophagy-lysosomal pathwayElectroacupuncture→TFEBTFEB→BECN1
▸ Show 3 more
TRIM27→TFEBTFEB→autophagyCREB1→TFEB

associated with (2)

GABA→TFEBTFEB→endocytosis

inhibits (2)

IL6→TFEBAKT-MAPK1-MTORC1 pathway→TFEB

regulates (8)

TFEB→RRAGDTFEB→PPARGC1ATFEB→autophagyPPARA→TFEBTFEB→lysosomal biogenesis
▸ Show 3 more
TFEB→autophagy-lysosomal pathwayTFEB→LC3TFEB→RRAG

Debate History (1)

Should TFEB (TFEB Protein) be prioritized as a therapeutic target for neurodegen2026-04-26
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