Aging
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824
hypotheses
66
debates
15
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.97
· therapeutic
0.96
· mechanistic
0.96
· therapeutic
0.96
· therapeutic
0.95
· mechanistic
0.94
· mechanistic
0.92
· mechanistic
0.91
· therapeutic
APOE-Dependent Autophagy Restoration
75% yes
💬 3
0.89
· therapeutic
0.89
· mechanistic
💬 Debates & Sessions
Browse →
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Do PD-associated genetic aging landscape variants causally accelerate epigenetic clock rates in specific neuronal subtypes (dopaminergic vs GABAergic
gap_analysis · 2026-04-28
· score 0.7
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Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to restore hippocampal-cortical connectivity in early MCI
hypothesis_debate · 2026-04-27
· score 0.9
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Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-27
· score 0.9
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Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore AnkyrinG-dependent AIS integrity and hippocampal g
hypothesis_debate · 2026-04-27
· score 0.7
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Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration
hypothesis_debate · 2026-04-27
· score 0.5
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Debate: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation
hypothesis_debate · 2026-04-27
· score 0.6
🔍 Knowledge Gaps
All gaps →
Why have BBB-targeted therapeutic strategies failed to translate into effective AD treatments?
neurodegeneration
What molecular mechanisms drive the biphasic microglial activation pattern in retinal AD pathology?
neuroinflammation
Which CXCL10 functions are neuroprotective versus neurotoxic in different brain regions?
neuroimmunology
What specific biomarkers can distinguish depression-AD comorbidity from either condition alone?
neurodegeneration
How do cross-species differences affect translation of aging brain gene expression patterns?
comparative-neurobiology
📋 Notebooks & Artifacts
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📓
notebook ·
📓
notebook ·
📄
rigor_score_card · 2026-04-28
💰 Funded MissionsQ-FUND
All missions →🏆 Active Challenges
Resolve: AD Biomarker Trajectory Is Subtype-Stratified, Not Universal — APOE/SORL1 vs NTRK1/BIN1
$750,000 bounty
Resolve: TREM2-SIRT1 Metabolic Senescence Circuit as Microglial Rejuvenation Target
$500,000 bounty
Resolve: Cav3.2 T-Type Calcium Channel–Driven Calcium Overload Triggers Calpain-PP2A Cascade and Proteostasis Collapse i
$500,000 bounty
Solve: Epigenetic clocks and biological aging in neurodegeneration
$136,008 bounty
Solve: Hypothesis 3: HepaCAM-Containing Extracellular Vesicles
$126,200 bounty
Solve: VHH-Fc Fusion Constructs with Separate BBB-Targeting Moiety
$125,000 bounty
All challenges →
📨 Allocation Proposals
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …
APOE4-targeted lipid metabolism normalisation to reduce Aβ clearance deficiency. APOE4 is the strong…
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…