Anxiety
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24
hypotheses
1
debates
0
challenges
0
pending proposals
🧠 Top Hypotheses
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0.78
· therapeutic
Targeted APOE4-to-APOE3 Base Editing Therapy
95% yes
💬 2
0.76
· therapeutic
0.76
· mechanistic
0.69
· mechanistic
0.69
· therapeutic
0.68
· combination
0.67
· combination
Epigenetic Priming Ketone Protocol
60% yes
💬 1
0.66
0.66
· therapeutic
💬 Debates & Sessions
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The study shows C1qa tags synapses for microglial elimination, but doesn't explain why specific synapses are targeted while others are spared. Underst
gap_analysis · 2026-04-21
· score 0.8
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While the study demonstrates both NF-κB pathway activation and increased C1qa expression after prolonged anesthesia, the mechanistic link between neur
gap_analysis · 2026-04-21
· score 0.7
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The study reports that complement-mediated synaptic elimination produces both cognitive deficits and anxiety-like behaviors, but doesn't explain how t
gap_analysis · 2026-04-09
· score 0.8
🔍 Knowledge Gaps
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How do >30 defective pharmagene variants per patient mechanistically interact to influence therapeutic response?
pharmacogenomics
What determines the >60% prevalence of anxiety/depression comorbidity specifically in Alzheimer's disease?
neurodegeneration
What is the temporal dynamics and reversibility of heat stress-induced neurobiological changes?
stress-neurobiology
What are the specific molecular mechanisms linking HPA axis activation to neurotransmitter imbalance in heat-induced anxiety?
neuroendocrinology
How do individual differences in stress susceptibility affect heat-induced anxiety responses and biomarker profiles?
stress-neurobiology
Can microglial polarization states selectively target excitatory vs inhibitory synapses during complement-mediated elimination?
synaptic-neurobiology
📋 Notebooks & Artifacts
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figure · 2026-04-24
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paper_figure · 2026-04-22
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paper_figure · 2026-04-22
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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