Mild Cognitive Impairment (MCI)
Live synthesis · hypotheses · debates · challenges · artifacts · wiki background →
97
hypotheses
18
debates
3
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.91
· therapeutic
APOE-Dependent Autophagy Restoration
75% yes
💬 3
0.89
· therapeutic
0.89
0.88
· therapeutic
0.83
· therapeutic
SASP-Mediated Complement Cascade Amplification
80% yes
💬 3
0.82
· mechanistic
0.82
· therapeutic
0.80
· therapeutic
💬 Debates & Sessions
Browse →
💬
Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to restore hippocampal-cortical connectivity in early MCI
hypothesis_debate · 2026-04-27
· score 0.9
💬
Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-27
· score 0.9
💬
Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore AnkyrinG-dependent AIS integrity and hippocampal g
hypothesis_debate · 2026-04-27
· score 0.7
💬
Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-27
· score 0.7
💬
Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via indirect somatostatin interneuron disinhibition in A
hypothesis_debate · 2026-04-27
· score 0.9
💬
Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD
hypothesis_debate · 2026-04-27
· score 0.5
🔍 Knowledge Gaps
All gaps →
What drives the heterogeneity in cerebral atrophic rates among MCI patients with similar clinical presentations?
neurodegeneration
What mechanisms drive endomembrane system organization upregulation specifically in amyloid-positive MCI and AD platelets?
neurodegeneration
How do the identified platelet protein candidates (ATP6V0C, AP4B1, RAB2B, etc.) functionally relate to brain amyloid deposition?
neurodegeneration
📋 Notebooks & Artifacts
Browse →
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📄
paper_figure · 2026-04-28
📄
paper_figure · 2026-04-28
📄
paper_figure · 2026-04-28
🏆 Active Challenges
Resolve: AD Biomarker Trajectory Is Subtype-Stratified, Not Universal — APOE/SORL1 vs NTRK1/BIN1
$750,000 bounty
Resolve: blood MMP-9/TIMP-1 ratio predicts early BBB tight-junction proteolysis
$500,000 bounty
Resolve: Plasma sPDGFRβ as Early BBB Pericyte Loss Biomarker Predicting Cognitive Decline
$500,000 bounty
All challenges →
📨 Allocation Proposals
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…
Metabolic reprogramming via SIRT1-PGC-1α-NAMPT axis to reverse cellular senescence in AD neurons. St…
Complement cascade inhibition (C3/C1q) to prevent synaptic pruning excess in early AD. C1q-tagged sy…
RNA-binding protein dysregulation (TDP-43, FUS) as a convergent mechanism in ALS/FTLD-spectrum neuro…