Multiple Sclerosis (MS)
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95
hypotheses
1
debates
1
challenges
0
pending proposals
🧠 Top Hypotheses
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TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Failed DAM Transition
83% yes
💬 1
0.86
0.84
0.83
· mechanistic
0.81
· therapeutic
Neutrophil Extracellular Trap (NET) Inhibition
97% yes
💬 1
0.81
· therapeutic
0.80
· combination
0.77
· therapeutic
0.75
· therapeutic
💬 Debates & Sessions
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Test
gap_analysis · 2026-04-30
· score 0.7
💬
Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream across Alzheimer's disease, Parkinson's disease, ALS, and multiple scl
gap_analysis · 2026-04-28
· score 0.6
💬
The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendrocytes, but the specific neutralization mechanisms are not explained. U
gap_analysis · 2026-04-14
· score 0.7
💬
The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendrocytes, but the specific neutralization mechanisms are not explained. U
gap_analysis · 2026-04-14
· score 0.6
💬
The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendrocytes, but the specific neutralization mechanisms are not explained. U
gap_analysis · 2026-04-14
· score 0.9
🔍 Knowledge Gaps
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What drives the spatial restriction of stressed oligodendrocytes and reactive glia to MS plaque rims?
neuroinflammation
What are the specific molecular mechanisms linking gut dysbiosis to MS neurodegeneration and immune dysregulation?
neuroinflammation
What mechanisms drive selective vulnerability of CUX2+ upper cortical neurons to meningeal inflammation in MS?
neuroinflammation
What are the molecular mechanisms by which thyromimetics prevent oligodendrocyte death in neuroinflammation?
neurodegeneration
How does FGF2 simultaneously promote beneficial remyelination and detrimental neuroinflammation in MS?
neuroinflammation
📋 Notebooks & Artifacts
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📄
paper_figure · 2026-04-27
📄
rigor_score_card · 2026-04-26
📄
paper_figure · 2026-04-21
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paper_figure · 2026-04-21
📄
paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
🏆 Active Challenges
Solve: Oligodendrocyte Precursor Cell Senescence in White Matter Disease
$126,900 bounty
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📨 Allocation Proposals
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
Lysosomal acidification restoration via v-ATPase modulation to improve autophagic clearance of Aβ an…