The review identifies 8 major signaling pathways involved in MS but doesn't explain how their complex interactions determine disease progression or therapeutic responses. Understanding pathway crosstalk is critical for developing effective combination therapies. Gap type: open_question Source paper: Molecular mechanism and the main signaling pathways in the development and progression of multiple sclerosis. (2025, Experimental cell research, PMID:40992569)
Landscape Summary: What determines the context-dependent therapeutic potential across the multiple dysregulated pathways in MS? is a 0.71 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What determines the context-dependent therapeutic potential across the multiple dysregulated pathways in MS? — INVOKE-2 (completed)
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